Department of Pathology, University of Washington, Seattle, WA 98195, USA.
Aging Cell. 2011 Apr;10(2):185-90. doi: 10.1111/j.1474-9726.2010.00665.x. Epub 2011 Jan 20.
In this, the fourth installment of our annual Hot Topics review on mRNA translation and aging, we have decided to expand our scope to include recent findings related to the role of TOR signaling in aging. As new data emerge, it is clear that TOR signaling acts upstream of mRNA translation, as well as a variety of other cellular processes, to modulate longevity and healthspan in evolutionarily diverse species. This Hot Topics review will cover important new findings in this area that have occurred over the past year. These include the demonstration that the TOR substrate ribosomal S6 kinase modulates longevity in mammals, the potential for TOR inhibitors as therapeutic treatments for Alzheimer's disease, and further studies emphasizing the importance of differential translation of specific mRNAs for healthy aging and enhanced longevity.
在我们关于 mRNA 翻译和衰老的年度热门话题综述的第四期中，我们决定扩大范围，纳入最近与 TOR 信号在衰老中的作用相关的发现。随着新数据的出现，TOR 信号作为 mRNA 翻译以及各种其他细胞过程的上游，在进化上多样化的物种中调节寿命和健康跨度的作用变得越来越明显。这篇热门话题综述将涵盖过去一年中该领域的重要新发现。这些发现包括证明 TOR 底物核糖体 S6 激酶调节哺乳动物的寿命、TOR 抑制剂作为治疗阿尔茨海默病的潜在治疗方法，以及进一步强调特定 mRNA 差异翻译对健康衰老和延长寿命的重要性的研究。
