等离子体纳米气泡对组织的选择性和自主微消融。
Selective and self-guided micro-ablation of tissue with plasmonic nanobubbles.
机构信息
Joint American-Belarusian Laboratory for Fundamental and Biomedical Nanophotonics, Rice University, Houston, Texas 77005, USA.
出版信息
J Surg Res. 2011 Mar;166(1):e3-13. doi: 10.1016/j.jss.2010.10.039. Epub 2010 Nov 26.
BACKGROUND
The accuracy, selectivity, and safety of surgical and laser methods for tissue elimination are often limited at microscale.
MATERIALS AND METHODS
We developed a novel agent, the plasmonic nanobubble (PNB), for optically guided selective elimination of the target tissue with micrometer precision. PNBs were tested in vitro in the two different models of superficial tumors and vascular plaques.
RESULTS
PNBs were selectively generated around gold nanoparticles (delivered to the target tissues) with short laser pulses. Monolayers of cancerous cells and atherosclerotic plaque tissue were eliminated with PNBs with micrometer accuracy and without thermal and mechanical damage to collateral normal tissues. The effect of the PNB was dynamically controlled through the fluence of laser pulses (532 nm, duration 0.5 and 10 ns) and was guided through the optical scattering by PNB.
CONCLUSIONS
Plasmonic nanobubbles were shown to provide precise, tunable, selective, and guided ablation of tissue at a microscopic level and could be employed as a new generation of surgical tools.
背景
手术和激光方法在消除组织时的准确性、选择性和安全性在微尺度上往往受到限制。
材料与方法
我们开发了一种新型试剂，即等离子体纳米泡（PNB），用于通过光引导以微米级精度选择性地消除目标组织。在两种不同的浅层肿瘤和血管斑块模型中对 PNB 进行了体外测试。
结果
通过短激光脉冲可在金纳米颗粒（递送至靶组织）周围选择性地产生 PNB。用 PNB 以微米级精度消除单层癌细胞和动脉粥样硬化斑块组织，而不会对相邻正常组织造成热和机械损伤。通过激光脉冲的能量（532nm，持续时间为 0.5 和 10ns）动态控制 PNB 的效果，并通过 PNB 的光散射进行引导。
结论
等离子体纳米泡可在微观水平上提供精确、可调、选择性和引导性的组织消融，可作为新一代手术工具。
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