Chen Jing
Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, Canada K1A 1C1.
Radiat Prot Dosimetry. 2011 Feb;143(2-4):436-9. doi: 10.1093/rpd/ncq394. Epub 2010 Dec 20.
Proton beams are of growing interest for radiation therapy due to their special physical and radiobiological properties. Microdosimetric characteristics of proton beams have strong influence on the relative biological effectiveness for each biological system. This study focused on the microdosimetric characteristics of monoenergetic protons from 50 keV to 200 MeV. Monte Carlo techniques were used to simulate track segments of protons in water. Dose mean lineal energies were derived to characterise proton beams with changing kinetic energy and changing radiation qualities at various depths and within spread-out Bragg peaks of clinic interests.
由于质子束特殊的物理和放射生物学特性,其在放射治疗中的应用越来越受到关注。质子束的微剂量学特征对每个生物系统的相对生物效应有很大影响。本研究聚焦于能量从50 keV至200 MeV的单能质子的微剂量学特征。采用蒙特卡罗技术模拟质子在水中的径迹段。通过推导剂量平均线能量来表征不同动能、不同辐射品质、在不同深度以及在临床感兴趣的扩展布拉格峰内的质子束。