Eze Boniface I, Ibegbulam Godswill O, Ocheni Sunday
Department of Ophthalmology, University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, PMB 01139, Enugu, Nigeria.
Middle East Afr J Ophthalmol. 2010 Oct;17(4):325-9. doi: 10.4103/0974-9233.71599.
To determine the prevalence and pattern of leukemic ophthalmopathy among adults at the University of Nigeria Teaching Hospital (UNTH), Enugu, south-eastern, Nigeria.
This prospective, observational case series surveyed adult leukemia patients presenting at UNTH's departments of Hematology/Immunology and Ophthalmology from July 2003 to August 2008. The demographic profile, clinical data from for each individual in the cohort were statistically collated and analyzed. A P <0.05 was considered as statistically significant.
There were 72 participants (45 males and 27 females), aged 32.7 ± 9.8 years (range, 18 years to 72 years). Leukemic ophthalmopathy was present in 77.8% of subjects. The leading ophthalmic manifestations of leukemia were retinal vascular abnormalities in 50.0% of subjects, conjunctival pallor in 27.8% of subjects, sub-conjunctival hemorrhage in 19.4% of subjects, and retinal hemorrhage in 16.7% of subjects. Ocular co-morbidity was present in 47.2% of subjects. Vision loss occurred in 37.5% of subjects, of which 32.1% was leukemia related, and the remaining due to ocular co-morbidity. Leukemic ophthalmopathy was more prevalent in chronic leukemia (P <0.05), frequently affected the ocular posterior segment (P < 0.05), and often resulted from secondary hematologic complications (P <0.05). There was no gender difference in the prevalence of leukemia (P = 0.0822) or leukemic ophthalmopathy (P = 0.6624).
The prevalence of leukemic ophthalmopathy in Enugu is high. It is often associated with significant ocular co-morbidity and vision loss. These have implications for clinicians involved in leukemia management. Early diagnosis and regular ophthalmic examinations are recommended to optimize treatment outcomes.
确定尼日利亚东南部埃努古的尼日利亚大学教学医院（UNTH）成人白血病性眼病的患病率及模式。
本前瞻性观察性病例系列研究对2003年7月至2008年8月在UNTH血液学/免疫学和眼科就诊的成年白血病患者进行了调查。对队列中每个个体的人口统计学资料、临床数据进行了统计学整理和分析。P<0.05被认为具有统计学意义。
共有72名参与者（45名男性和27名女性），年龄为32.7±9.8岁（范围为18岁至72岁）。77.8%的受试者存在白血病性眼病。白血病最主要的眼部表现为：50.0%的受试者有视网膜血管异常，27.8%的受试者有结膜苍白，19.4%的受试者有结膜下出血，16.7%的受试者有视网膜出血。47.2%的受试者存在眼部合并症。37.5%的受试者出现视力丧失，其中32.1%与白血病相关，其余与眼部合并症有关。白血病性眼病在慢性白血病中更为常见（P<0.05），常累及眼后段（P<0.05），且常由继发性血液学并发症引起（P<0.05）。白血病患病率（P = 0.0822）或白血病性眼病患病率（P = 0.6624）在性别上无差异。
埃努古白血病性眼病的患病率很高。它常伴有明显的眼部合并症和视力丧失。这些对参与白血病治疗的临床医生具有重要意义。建议早期诊断并定期进行眼科检查以优化治疗效果。
