Röcker L, Taenzer M, Drygas W K, Lill H, Heyduck B, Altenkirch H U
Institut für Leistungsmedizin (LLZ), FU Berlin, Federal Republic of Germany.
Eur J Appl Physiol Occup Physiol. 1990;60(6):478-81. doi: 10.1007/BF00705040.
The effect of a test marathon race on plasma fibrinolytic activity (FA) was studied in 16 endurance athletes before, immediately after, 3 h, and 31 h after the run. Tissue plasminogen activator (t-PA) activity increased about 31-fold immediately after the run. Similar increases were found in t-PA antigen concentration. Plasminogen activator inhibitor (PAI) was not detectable immediately after the race and was significantly decreased 3 h (P less than 0.05) and 31 h (P less than 0.01) later. B beta 15-42 peptide increased by 0.63 pmol.ml-1 (P less than 0.001), D-dimer by 68.3 ng.ml-1 (P less than 0.05). Euglobulin lysis time (ELT) was reduced from 109 to 18 min (P less than 0.001). The increased t-PA activity and t-PA antigen concentration disappeared in the course of the first 3 h after exertion. ELT also reached its pre-exercise levels at this time. Thirty-one hours after the race ELT and t-PA antigen levels were slightly but significantly reduced (P less than 0.05), whereas B beta 15-42 peptide remained increased (P less than 0.05). t-PA activity was unchanged compared with pre-exercise values. It seems that the exercise-induced FA is mainly caused by the marked increase of t-PA antigen and t-PA activity.
在16名耐力运动员中，研究了一场马拉松测试赛对血浆纤维蛋白溶解活性（FA）的影响，分别在赛前、赛后即刻、赛后3小时和31小时进行检测。赛后即刻，组织纤溶酶原激活物（t-PA）活性增加了约31倍。t-PA抗原浓度也有类似的增加。赛后即刻未检测到纤溶酶原激活物抑制剂（PAI），3小时后（P<0.05）和31小时后（P<0.01）显著降低。Bβ15-42肽增加了0.63 pmol/ml（P<0.001），D-二聚体增加了68.3 ng/ml（P<0.05）。优球蛋白溶解时间（ELT）从109分钟缩短至18分钟（P<0.001）。运动后最初3小时内，t-PA活性和t-PA抗原浓度的增加消失。此时ELT也恢复到运动前水平。赛后31小时，ELT和t-PA抗原水平略有下降但具有显著性（P<0.05），而Bβ15-42肽仍升高（P<0.05）。与运动前值相比，t-PA活性未发生变化。运动诱导的FA似乎主要是由t-PA抗原和t-PA活性的显著增加所引起。
