Department of Natural Resources and Environmental Management, Graduate School of Management, University of Haifa, Haifa, Israel.
Chronobiol Int. 2011 Feb;28(1):76-80. doi: 10.3109/07420528.2010.531490.
Due to its disruptive effects on circadian rhythms and sleep deprivation at night, shiftworking is currently recognized as a risk factor for breast cancer (BC). As revealed by the present analysis based on a comparative case-control study of 1679 women, exposure to light-at-night (LAN) in the "sleeping habitat" is significantly associated with BC risk (odds ratio [OR] = 1.220, 95% confidence interval [CI] = 1.118-1.311; p < .001), controlling for education, ethnicity, fertility, and alcohol consumption. The novelty of the present research is that, to the best of the authors' knowledge, it is the first study to have identified an unequivocal positive association between bedroom-light intensity and BC risk. Thus, according to the results of the present study, not only should artificial light exposure in the working environment be considered as a potential risk factor for BC, but also LAN in the "sleeping habitat."
由于轮班工作对昼夜节律和夜间睡眠剥夺的干扰作用，目前已经将其认定为乳腺癌（BC）的一个风险因素。本研究基于对 1679 名女性的病例对照研究进行了分析，结果表明，“睡眠环境”中的夜间光照（LAN）与 BC 风险显著相关（比值比 [OR] = 1.220，95%置信区间 [CI] = 1.118-1.311；p < .001），校正了教育、种族、生育和饮酒等因素。本研究的新颖之处在于，据作者所知，这是第一项确定卧室灯光强度与 BC 风险之间存在明确正相关关系的研究。因此，根据本研究的结果，不仅应该将工作环境中的人工光照暴露视为 BC 的潜在风险因素，还应该将“睡眠环境”中的 LAN 视为潜在风险因素。
