Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of Sao Paulo Medical School, Brazil.
Am J Hypertens. 2011 Mar;24(3):278-84. doi: 10.1038/ajh.2010.244. Epub 2010 Dec 23.
The impact of increased central arterial stiffness as a predictor of morbidity and mortality, independently of other cardiovascular (CV) risk factors, has been established. The main aim of the present work was to investigate the association of ethnicity on arterial stiffness in different ethnic groups from the Brazilian population.
A total of 1,427 individuals from the general population were randomly selected from the Vitoria City metropolitan area and 588 Amerindians from a native community in Brazil. The ethnicity of the general population was classified by a standard questionnaire as Caucasian descent, African descent, or Mulattos (considered racially mixed subjects). Pulse wave velocity (PWV) was measured with a noninvasive automatic device (Complior, Colson; Garges les Gonesses, France).
Hemodynamic data of PWV, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) was higher in African descent individuals than in the other groups (P < 0.001). These results were still observed after adjustment for age and mean arterial pressure (P < 0.001). In addition, studying only normotensive individuals, PWV adjusted levels were higher in African descent individuals, and lower in Amerindians when compared with other ethnic groups (P < 0.01), showing, without the possible confounder effects of time and severity of hypertension or medication use, that PWV is associated with ethnicity in our population.
The study of different ethnic groups from a highly admixtured population was able to demonstrate an association between ethnicity and arterial stiffness.
已证实，中央动脉僵硬度增加作为发病率和死亡率的预测因子，其独立于其他心血管（CV）危险因素。本研究的主要目的是调查巴西人群不同种族之间的动脉僵硬度与种族的关系。
从维多利亚市大都市区随机选择了 1427 名普通人群个体，以及巴西一个土著社区的 588 名美洲印第安人。普通人群的种族通过标准问卷分为白种人、黑种人或穆拉托人（被认为是种族混合的人）。脉搏波速度（PWV）使用非侵入性自动设备（Complior，Colson；Garges les Gonesses，法国）进行测量。
与其他群体相比，黑种人个体的血流动力学 PWV、收缩压（SBP）、舒张压（DBP）和平均血压（MBP）数据更高（P<0.001）。即使在调整年龄和平均动脉压后，这些结果仍然存在（P<0.001）。此外，仅研究正常血压个体时，与其他种族相比，黑种人个体的 PWV 调整水平更高，而美洲印第安人个体的 PWV 调整水平更低（P<0.01），表明在没有高血压时间和严重程度或药物使用等可能的混杂因素的影响下，PWV 与我们人群的种族有关。
对来自高度混合人群的不同种族进行的研究表明，种族与动脉僵硬度之间存在关联。
