Ecotoxicology and Environmental Fish Health Program, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration Fisheries, 2725 Montlake Boulevard East, Seattle, Washington 98112, USA.
Integr Environ Assess Manag. 2011 Jan;7(1):2-6. doi: 10.1002/ieam.133.
Over the past few years, the "critical body residue" approach for assessing toxicity based on bioaccumulated chemicals has evolved into a more expansive consideration of tissue residues as the dose metric when defining dose-response relationships, evaluating mixtures, developing protective guidelines, and conducting risk assessments. Hence, scientists refer to "tissue residue approach for toxicity assessment" or "tissue residue-effects approach" (TRA) when addressing ecotoxicology issues pertaining to tissue (or internal) concentrations. This introduction provides an overview of a SETAC Pellston Workshop held in 2007 to review the state of the science for using tissue residues as the dose metric in environmental toxicology. The key findings of the workshop are presented, along with recommendations for research to enhance understanding of toxic responses within and between species, and to advance the use of the TRA in assessment and management of chemicals in the environment.
在过去的几年中，基于生物蓄积化学物质评估毒性的“关键身体残留”方法已经发展成为更广泛的考虑组织残留作为定义剂量反应关系、评估混合物、制定保护准则和进行风险评估的剂量指标。因此，当涉及与组织（或内部）浓度有关的生态毒理学问题时，科学家们会使用“毒性评估的组织残留方法”或“组织残留效应方法”（TRA）。本引言概述了 2007 年在 SETAC 佩尔斯顿举办的一次研讨会，该研讨会旨在审查将组织残留作为环境毒理学中剂量指标的科学现状。介绍了研讨会的主要发现，并提出了加强对物种内和物种间毒性反应的理解以及推进在环境中化学物质评估和管理中使用 TRA 的研究建议。
