唾液淀粉酶作为口腔癌放疗患者唾液腺功能的标志物。
Salivary Amylase as a Marker of Salivary Gland Function in Patients Undergoing Radiotherapy for Oral Cancer.
作者信息
Vedam V K Vaishnavi, Boaz Karen, Natarajan Srikant, Ganapathy Sivadas
机构信息
Department of Oral Pathology & Microbiology, Faculty of Dentistry, Asian Institute of Medicine, Science and Technology (AIMST) University, Kedah, Malaysia.
Department of Oral Pathology & Microbiology, Manipal College of Dental Sciences, Mangalore, Manipal University, Mangalore, India.
出版信息
J Clin Lab Anal. 2017 May;31(3). doi: 10.1002/jcla.22048. Epub 2016 Sep 17.
BACKGROUND
The aim of this study was to evaluate salivary amylase in patients with primary oral cancer undergoing radiotherapy as the main modality of treatment.
MATERIALS/METHODS: The study was conducted on ten histologically proven cases of oral cancer undergoing radiotherapy. Stimulated whole saliva was collected at three stages of radiotherapy-0, 3, and 6 weeks. Salivary amylase was estimated using Henry-Chiamori method and comparison was made with appropriate age- and gender-matched controls.
RESULTS
Salivary amylase levels showed significant decrease in healthy subjects when compared to oral cancer patients (P < 0.001). The latter group also showed changing trend with initial decrease from 0 to 3 weeks followed by increase from 3 to 6 weeks following radiotherapy (P < 0.0528).
CONCLUSIONS
The trend in changes in the levels of salivary amylase could be used as a surrogate marker of salivary gland function in patients with oral cancer undergoing radiotherapy as primary treatment.
背景
本研究的目的是评估接受放射治疗作为主要治疗方式的原发性口腔癌患者的唾液淀粉酶。
材料/方法：本研究对10例经组织学证实的接受放射治疗的口腔癌病例进行。在放射治疗的三个阶段——0周、3周和6周——收集刺激后的全唾液。使用亨利-恰莫里方法测定唾液淀粉酶，并与年龄和性别匹配的适当对照组进行比较。
结果
与口腔癌患者相比，健康受试者的唾液淀粉酶水平显著降低（P < 0.001）。后一组在放射治疗后也呈现出变化趋势，从0周开始至3周下降，随后从3周升至6周（P < 0.0528）。
结论
唾液淀粉酶水平的变化趋势可作为接受放射治疗作为主要治疗的口腔癌患者唾液腺功能的替代标志物。
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