Biophysics Units, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
Oral Dis. 2013 Sep;19(6):585-91. doi: 10.1111/odi.12039. Epub 2012 Nov 22.
Here we determine the relationship between salivary levels of mucin and amylase and the clinical parameters of periodontal disease before and after periodontal treatment.
Ninety two subjects were clinically examined and distributed into four groups namely clinically healthy, mild, moderate and severe periodontitis, according to the periodontal status, classified according the values of clinical attachment level (CAL) and probing pocket depth (PPD). Unstimulated saliva was collected for 5 min. Salivary proteins, amylase and mucin were determined by colorimetric methods.
A significant positive correlation (P < 0.0001) was observed between salivary mucin, amylase or protein and PPD or CAL before periodontal treatment while flow rate showed a negative correlation. Mucin and amylase output also showed a positive correlation with PPD or CAL. After treatment, the improvement of clinical parameters was accompanied by a diminution of salivary mucin, amylase or protein concentration and output in moderate and severe group.
The increment of mucin and amylase output in relation to periodontal status indicates that salivary glands respond to the disease by increasing the protective potential of saliva when necessary and return to the normal rate of secretion after the resolution of the inflammatory process.
本研究旨在探讨牙周治疗前后唾液中黏蛋白和淀粉酶水平与牙周病临床参数之间的关系。
92 名受试者根据牙周状况，按照临床附着水平（CAL）和探诊袋深度（PPD）值进行分类，分为临床健康、轻度、中度和重度牙周炎 4 组。采用分光光度法检测唾液蛋白、淀粉酶和黏蛋白。
牙周治疗前，唾液黏蛋白、淀粉酶或蛋白与 PPD 或 CAL 呈显著正相关（P<0.0001），而流速呈负相关。黏蛋白和淀粉酶的分泌量与 PPD 或 CAL 也呈正相关。治疗后，中重度组临床参数改善的同时，唾液黏蛋白、淀粉酶或蛋白浓度和分泌量均降低。
黏蛋白和淀粉酶分泌量的增加与牙周状况有关，这表明当需要时，唾液腺通过增加唾液的保护潜力来应对疾病，并且在炎症过程得到解决后，分泌速率恢复正常。
