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白细胞介素-2和白细胞介素-6在“常见变异型”低丙种球蛋白血症患者T细胞有丝分裂原反应性中的作用

Role of interleukin-2 and interleukin-6 in the mitogen responsiveness of T cells from patients with 'common-variable' hypogammaglobulinaemia.

作者信息

North M E, Webster A D, Farrant J

机构信息

Immune Deficiency Diseases Research Group, Clinical Research Centre, Harrow, England.

出版信息

Clin Exp Immunol. 1990 Sep;81(3):412-6. doi: 10.1111/j.1365-2249.1990.tb05348.x.

DOI:10.1111/j.1365-2249.1990.tb05348.x
PMID:2118844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1534984/
Abstract

We have assessed the ability of interleukin-2 (IL-2) and interleukin-6 (IL-6) to augment the proliferative response of T lymphocytes from 'common-variable' hypogammaglobulinaemia (CVH) patients and from normal controls, to the mitogens phytohaemagglutinin (PHA) and OKT3. We show that with cells from the control group and from those patients whose T cells respond to PHA within the control range, both IL-2 and IL-6 will significantly augment the response to OKT3. However, in those patients with a T cell defect in which the PHA response is below the control range, neither IL-2 nor IL-6 could restore the PHA or OKT3 response to normal. Responses to IL-2 or IL-6 alone were always in or above the control range.

摘要

我们评估了白细胞介素-2（IL-2）和白细胞介素-6（IL-6）增强来自“常见变异型”低丙种球蛋白血症（CVH）患者及正常对照者的T淋巴细胞对丝裂原植物血凝素（PHA）和OKT3的增殖反应的能力。我们发现，对于对照组以及T细胞对PHA的反应在对照范围内的患者的细胞，IL-2和IL-6均能显著增强对OKT3的反应。然而，在那些T细胞存在缺陷且PHA反应低于对照范围的患者中，IL-2和IL-6均无法将PHA或OKT3反应恢复至正常。单独对IL-2或IL-6的反应始终在对照范围内或高于对照范围。

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本文引用的文献

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Conditions for measuring DNA synthesis in PHA stimulated human lymphocytes in 20 microliters hanging drops with various cell concentrations and periods of culture.在含有不同细胞浓度并培养不同时长的20微升悬滴中，测量PHA刺激的人淋巴细胞中DNA合成的条件。
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Interleukin-2 correction of defective in vitro T-cell mitogenesis in patients with common varied immunodeficiency.白细胞介素-2对普通变异型免疫缺陷患者体外T细胞有丝分裂缺陷的纠正作用。
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Signals involved in T cell activation. II. Distinct roles of intact accessory cells, phorbol esters, and interleukin 1 in activation and cell cycle progression of resting T lymphocytes.T细胞活化相关信号。II. 完整辅助细胞、佛波酯和白细胞介素1在静息T淋巴细胞活化及细胞周期进程中的不同作用。
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