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2
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Immunosuppressive activity of deer antler extracts of Cervus korean TEMMINCK var. mantchuricus Swinhoe, on type II collagen-induced arthritis.梅花鹿（Cervus korean TEMMINCK var. mantchuricus Swinhoe）鹿茸提取物对Ⅱ型胶原诱导性关节炎的免疫抑制活性
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本文引用的文献

1
Serum transfer of collagen-induced arthritis in mice.小鼠胶原诱导性关节炎的血清转移
J Exp Med. 1983 Aug 1;158(2):378-92. doi: 10.1084/jem.158.2.378.
2
Specificity of anti-type II collagen antibody response in rats.大鼠抗II型胶原抗体反应的特异性
Clin Exp Immunol. 1984 Jul;57(1):57-62.
3
Collagen autoimmune arthritis.胶原性自身免疫性关节炎
Annu Rev Immunol. 1984;2:199-218. doi: 10.1146/annurev.iy.02.040184.001215.
4
Interferons with special emphasis on the immune system.特别关注免疫系统的干扰素。
Adv Immunol. 1983;34:97-140. doi: 10.1016/s0065-2776(08)60378-8.
5
Interferons: biochemical, cell growth inhibitory, and immunological effects.干扰素：生化、细胞生长抑制及免疫学效应。
Prog Hematol. 1981;12:299-339.
6
Immunisation against heterologous type II collagen induces arthritis in mice.针对异源II型胶原蛋白进行免疫接种会在小鼠中诱发关节炎。
Nature. 1980 Feb 14;283(5748):666-8. doi: 10.1038/283666a0.
7
Structural studies on cartilage collagen employing limited cleavage and solubilization with pepsin.利用胃蛋白酶进行有限裂解和溶解对软骨胶原蛋白进行的结构研究。
Biochemistry. 1972 Dec 19;11(26):4903-9. doi: 10.1021/bi00776a005.
8
Evaluation of the effects of various anti-arthritic drugs on type II collagen-induced mouse arthritis model.评估各种抗关节炎药物对Ⅱ型胶原诱导的小鼠关节炎模型的影响。
Immunopharmacology. 1985 Aug;10(1):51-60. doi: 10.1016/0162-3109(85)90059-1.
9
[Interferon in chronic polyarthritis. Positive effect in clinical evaluation].[慢性多关节炎中的干扰素。临床评估中的积极效果]
Dtsch Med Wochenschr. 1985 Nov 15;110(46):1766-9. doi: 10.1055/s-2008-1069083.
10
Treatment with gamma-interferon triggers the onset of collagen arthritis in mice.用γ-干扰素治疗会引发小鼠胶原性关节炎。
Arthritis Rheum. 1988 Oct;31(10):1297-304. doi: 10.1002/art.1780311012.

γ-干扰素治疗对Ⅱ型胶原诱导性关节炎的影响。

The effect of treatment with interferon-gamma on type II collagen-induced arthritis.

作者信息

Nakajima H, Takamori H, Hiyama Y, Tsukada W

机构信息

Research Institute, Daiichi Pharmaceutical Co., Tokyo, Japan.

出版信息

Clin Exp Immunol. 1990 Sep;81(3):441-5. doi: 10.1111/j.1365-2249.1990.tb05353.x.

DOI:10.1111/j.1365-2249.1990.tb05353.x
PMID:2118846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1534996/
Abstract

We have investigated the effects of recombinant murine interferon-gamma (rIFN-gamma) on type II collagen-induced arthritis (CA) in DBA/l mice. Therapeutic as well as prophylactic treatment with subcutaneous rIFN-gamma, at 10(5) U/mouse six times a week, inhibited the development of CA without any obvious side effects. The accompanying suppression of anti-CII antibody responses may partly explain the inhibition of CA by rIFN-gamma. The possible role of the anti-inflammatory effect of systemic IFN-gamma in the inhibition of CA is discussed.

摘要

我们研究了重组鼠干扰素-γ（rIFN-γ）对DBA/l小鼠II型胶原诱导性关节炎（CA）的影响。每周六次皮下注射rIFN-γ，剂量为10⁵ U/小鼠，无论是治疗还是预防性治疗，均能抑制CA的发展，且无明显副作用。伴随的抗CII抗体反应的抑制可能部分解释了rIFN-γ对CA的抑制作用。本文讨论了全身IFN-γ的抗炎作用在抑制CA中可能发挥的作用。