Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, 482 001, India.
J Mater Sci Mater Med. 2010 May;21(5):1573-86. doi: 10.1007/s10856-010-3997-5. Epub 2010 Feb 5.
Gelatin (Type B) nanoparticles were prepared by a single W/O emulsion technique and characterized by infrared (IR) spectra, transmission electron micrographs (TEM), surface potential measurements and magnetization studies. Whereas the IR spectra clearly confirmed the presence of gelatin, genipin and doxorubicin in the loaded nanoparticles, the transmission electron micrographs (TEM) image depicts smooth surface, spherical shape and non-uniform size of nanoparticles (up to 100 nm). The prepared nanoparticles were loaded with doxorubicin, a well known anticancer drug, and in vitro release dynamics of entrapped drug was investigated as a function of various experimental factors such as percent loading of the drug, chemical architecture of the nanocarriers, and pH, temperature, ionic strength and nature of the release medium in presence and absence of magnetic field. The nanoparticles were also studied for their water sorption capacity. The drug release process was analyzed kinetically using Ficks power law and a correlation was established between the quantity of released drug and swelling of the nanoparticles.
明胶（B 型）纳米颗粒通过单 W/O 乳液技术制备，并通过红外（IR）光谱、透射电子显微镜（TEM）、表面电位测量和磁化研究进行表征。虽然 IR 光谱清楚地证实了负载纳米颗粒中存在明胶、京尼平苷和阿霉素，但透射电子显微镜（TEM）图像描绘了纳米颗粒的光滑表面、球形形状和非均匀尺寸（可达 100nm）。所制备的纳米颗粒负载了阿霉素，一种众所周知的抗癌药物，并研究了包封药物的体外释放动力学作为各种实验因素的函数，例如药物的负载百分比、纳米载体的化学结构以及存在和不存在磁场时释放介质的 pH 值、温度、离子强度和性质。还研究了纳米颗粒的吸水性。使用菲克定律对药物释放过程进行了动力学分析，并建立了释放药物的数量与纳米颗粒溶胀之间的相关性。
