Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.
Obes Surg. 2012 Feb;22(2):201-7. doi: 10.1007/s11695-010-0346-1.
The increased incidence of alcohol use disorders (AUD) after bariatric surgery has been proposed despite limited empirical support. We sought to determine the prevalence of current and lifetime AUD and other Axis I diagnoses in patients who have undergone bariatric surgery, and to test the hypothesis that greater weight loss is associated with a higher incidence of AUD following surgery.
Individuals who underwent bariatric surgery between 2004 and 2007 were recruited for inclusion in the study. The diagnosis of current and lifetime AUD and other Axis I disorders was assessed using the Structured Clinical Interview for DSM-IV.
A total of 51 individuals were included. The prevalence of lifetime and current AUD was 35.3% and 11.8%, respectively. No associations were found between weight loss following surgery and the development of an AUD or other Axis I diagnoses. Significantly more current AUD was reported in (1) individuals with a lifetime history of AUD compared to those without a lifetime AUD (p < 0.05), and (2) individuals undergoing Roux-en-Y gastric bypass (RYGB) compared to those undergoing the laparoscopic adjustable gastric banding (LAGB) surgery (p < 0.05).
Individuals undergoing bariatric surgery were found to have a lifetime prevalence of AUD comparable to the general population. Although weight loss was not associated with the development of an AUD following surgery, individuals with a lifetime history of AUD may be at increased risk for relapsing to alcohol use after surgery. All instances of current AUD were identified in individuals undergoing RYGB as opposed to LAGB.
尽管有限的实证支持,仍有研究提出减重手术后酒精使用障碍(AUD)的发病率增加。我们旨在确定接受过减重手术的患者中当前和终生 AUD 及其他轴 I 诊断的患病率,并检验体重减轻与手术后 AUD 发生率增加相关的假设。
在 2004 年至 2007 年间接受减重手术的个体被招募入组。使用 DSM-IV 结构临床访谈对当前和终生 AUD 及其他轴 I 障碍进行诊断。
共纳入 51 名个体。终生和当前 AUD 的患病率分别为 35.3%和 11.8%。手术后体重减轻与 AUD 或其他轴 I 诊断的发展之间没有关联。与无终生 AUD 相比,(1)有终生 AUD 病史的个体(p<0.05)和(2)行 Roux-en-Y 胃旁路术(RYGB)的个体(p<0.05)报告当前 AUD 的比例显著更高。
接受减重手术的个体终生 AUD 的患病率与一般人群相当。尽管体重减轻与手术后 AUD 的发生无关,但有终生 AUD 病史的个体在手术后可能有更高的复饮风险。当前 AUD 的所有病例均在接受 RYGB 的个体中发现,而非 LAGB。