2006-2007 年 SENTRY 抗菌药物监测计划：印度医院中产生 NDM-1 和 OXA-181 的肠杆菌科细菌的早期传播。
Early dissemination of NDM-1- and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006-2007.
机构信息
JMI Laboratories, North Liberty, Iowa 52317, USA.
出版信息
Antimicrob Agents Chemother. 2011 Mar;55(3):1274-8. doi: 10.1128/AAC.01497-10. Epub 2010 Dec 28.
Abstract
Among 39 carbapenem-resistant Enterobacteriaceae (2.7% overall; Escherichia coli, Enterobacter cloacae, and Klebsiella pneumoniae strains) isolated in 2006 and 2007 in India, 15 strains carried bla(NDM-1) and 10 harbored a gene encoding a variant of the carbapenemase OXA-48, named bla(OXA-181). One E. cloacae strain harbored bla(VIM-6), and one K. pneumoniae strain carrying bla(OXA-181) also possessed bla(VIM-5). Multiple pulsed-field gel electrophoresis patterns and clonal dissemination within and among sites were observed. Isolates producing NDM-1 were disseminated in Indian health care facilities as early as 2006.
摘要
在 2006 年至 2007 年期间，印度共分离出 39 株耐碳青霉烯肠杆菌科细菌（总体占比 2.7%，包括大肠杆菌、阴沟肠杆菌和肺炎克雷伯菌），其中 15 株携带 bla(NDM-1)，10 株携带编码碳青霉烯酶 OXA-48 变体的基因，命名为 bla(OXA-181)。1 株阴沟肠杆菌携带 bla(VIM-6)，1 株携带 bla(OXA-181)的肺炎克雷伯菌也携带 bla(VIM-5)。观察到多种脉冲场凝胶电泳图谱和同一地点及不同地点之间的克隆传播。早在 2006 年，产生 NDM-1 的分离株就已在印度医疗机构中传播。
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