Scorei Ion Romulus
University of Craiova, Biochemistry Department, A.I.Cuza, street, no.13, Craiova, Romania, East Europe.
Front Biosci (Schol Ed). 2011 Jan 1;3(1):205-15. doi: 10.2741/s145.
It was predicted that more B-containing molecules will be discovered that will prove useful in applications involving cell surface signaling, but insufficient progress was made in this general direction. The main objective of this review is to reveal other promising research directions for B-chemoprevention and chemotherapy using Calcium Fructoborate (CF). Targets include breast cancer, prostate cancer, lung cancer and cervical cancer. CF has been identified as Ca ( (C6H10O6)2B)2o4H2O and is a natural product from plants (can be produced by chemical synthesis as well), and is efficient in the prevention and treatments (as adjuvant) of osteoporosis and osteoarthritis. CF showed inhibitory effects on MDA-MB-231 breast cancer cells as well, and enters the cell (most likely) by a co-transport mechanism via a sugar transporter. Inside cells CF acts as an antioxidant and induces the overexpression of apoptosis-related proteins and eventually apoptosis.
据预测，将会发现更多含硼分子，它们在涉及细胞表面信号传导的应用中被证明是有用的，但在这个总体方向上进展不足。本综述的主要目的是揭示使用果糖硼酸钙（CF）进行硼化学预防和化疗的其他有前景的研究方向。目标包括乳腺癌、前列腺癌、肺癌和宫颈癌。CF已被鉴定为Ca((C6H10O6)2B)2o4H2O，是一种植物天然产物（也可通过化学合成生产），在骨质疏松症和骨关节炎的预防和治疗（作为辅助剂）方面很有效。CF对MDA-MB-231乳腺癌细胞也有抑制作用，并（很可能）通过糖转运体的共转运机制进入细胞。在细胞内，CF作为抗氧化剂，诱导凋亡相关蛋白的过表达并最终导致细胞凋亡。
