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3,3'-二溴-5,5'-双-[(S)-l-薄荷氧基]-4,4'-(己烷-1,6-二亚氨基)二呋喃-2(5H)-酮

3,3'-Dibromo-5,5'-bis-[(S)-l-menth-yloxy]-4,4'-(hexane-1,6-diyldiimino)difuran-2(5H)-one.

作者信息

Wang Zhao-Yang, Song Xiu-Mei, Cai Yue-Peng, Mao Zheng-Zhou

机构信息

School of Chemistry and Environment, South China Normal University, Guangzhou 510631, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Jul 31;64(Pt 8):o1642. doi: 10.1107/S1600536808020333.

DOI:10.1107/S1600536808020333
PMID:21203330
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2962195/
Abstract

The title compound, C(34)H(54)Br(2)N(2)O(6), was obtained by the Michael addition-elimination reaction of (5S)-5-(l-menthyl-oxy)-3,4-dibromo-furan-2(5H)-one with 1,6-hexa-nediamine in the presence of triethyl-amine. The crystal structure contains two chiral five-membered furan-one rings, in twist and envelope conformations, and two six-membered cyclo-hexane rings in chair conformations.

摘要

标题化合物C(34)H(54)Br(2)N(2)O(6)是通过(5S)-5-(L-薄荷氧基)-3,4-二溴呋喃-2(5H)-酮与1,6-己二胺在三乙胺存在下的迈克尔加成-消除反应得到的。晶体结构包含两个呈扭曲和信封构象的手性五元呋喃-酮环，以及两个呈椅式构象的六元环己烷环。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a297/2962195/83e30eff5608/e-64-o1642-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a297/2962195/83e30eff5608/e-64-o1642-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a297/2962195/83e30eff5608/e-64-o1642-fig1.jpg

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本文引用的文献

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2
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Bioorg Med Chem Lett. 2003 May 19;13(10):1639-43. doi: 10.1016/s0960-894x(03)00282-8.