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（S）-3-溴-4-二烯丙基氨基-5-[(1R,2S,5R)-2-异丙基-5-甲基环己氧基]呋喃-2(5H)-酮

(S)-3-Bromo-4-diallyl-amino-5-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclo-hex-yloxy]furan-2(5H)-one.

作者信息

Fu Jian-Hua, Wang Zhao-Yang, Li Jian-Xiao, Tan Yue-He

机构信息

School of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 24;66(Pt 12):o3277. doi: 10.1107/S1600536810047173.

DOI:10.1107/S1600536810047173
PMID:21589558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3011618/
Abstract

The title compound, C(20)H(30)BrNO(3), was obtained via a tandem asymmetric Michael addition-elimination reaction of 3,4-dibromo-5-(S)-(l-menth-yloxy)-2(5H)-furan-one and diallyl-amine in the presence of potassium fluoride. In the mol-ecule, the five-membered furan-one ring is approximately planar [maximum atomic deviation = 0.030 (3) Å], and the six-membered cyclo-hexane ring adopts a chair conformation.

摘要

标题化合物C(20)H(30)BrNO(3)是通过3,4-二溴-5-(S)-(l-薄荷氧基)-2(5H)-呋喃酮与二烯丙基胺在氟化钾存在下进行串联不对称迈克尔加成-消除反应得到的。在分子中，五元呋喃酮环近似平面[最大原子偏差 = 0.030 (3) Å]，六元环己烷环呈椅式构象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/3011618/68b1e6156b52/e-66-o3277-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/3011618/5787125fd220/e-66-o3277-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/3011618/68b1e6156b52/e-66-o3277-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/3011618/5787125fd220/e-66-o3277-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/3011618/68b1e6156b52/e-66-o3277-fig2.jpg

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