(5S)-3-氯-5-[(1R,2S,5R)-2-异丙基-5-甲基-环己氧基]-4-(4-甲基-哌啶-1-基)呋喃-2(5H)-酮
(5S)-3-Chloro-5-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclo-hex-yloxy]-4-(4-methyl-piperidin-1-yl)furan-2(5H)-one.
作者信息
Wang Xiao-Mei, Fu Jian-Hua, Cai Song-Liang, Wang Zhao-Yang
机构信息
School of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China.
出版信息
Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 19;67(Pt 3):o656. doi: 10.1107/S1600536811005216.
The title compound, C(20)H(32)ClNO(3), was obtained via a tandem asymmetric Michael addition-elimination reaction of (5S)-3,4-dichloro-5-(l-menth-yloxy)furan-2(5H)-one and 4-methyl-piperidine in the presence of potassium fluoride. The furan-one ring is approximately planar [maximum atomic deviation = 0.022 (2) Å] while the cyclo-hexane ring adopts a chair conformation. Weak inter-molecular C-H⋯O hydrogen bonding is present in the crystal structure.
标题化合物C(20)H(32)ClNO(3)是通过(5S)-3,4-二氯-5-(l-薄荷氧基)呋喃-2(5H)-酮与4-甲基哌啶在氟化钾存在下进行串联不对称迈克尔加成-消除反应得到的。呋喃-酮环近似平面结构[最大原子偏差 = 0.022 (2) Å]，而环己烷环呈椅式构象。晶体结构中存在弱的分子间C-H⋯O氢键。
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