Division of Pharmaceutical Evaluation and Policy, Department of Pharmacy Practice, University of Arkansas for Medical Sciences, 4301 W. Markham St., #522, Little Rock, AR 72205, USA.
Qual Life Res. 2011 Nov;20(9):1487-95. doi: 10.1007/s11136-011-9870-2. Epub 2011 Feb 24.
This research explores the sensitivity of three generic instruments for preference-weighting health states of family caregivers of children with craniofacial malformations (CFM). We also examine the construct validity of the new CarerQol instrument measuring caregiver burden and general quality of life.
Caregivers of children born with CFM were identified through the Arkansas Reproductive Health Monitoring System. A mailed survey included the HUI3, the SF-6D, the QWB-SA to measure health-related quality of life; the CES-D measuring depressive symptoms as well as the SRB scale, and the CarerQol. The HUI3, the SF-6D, and the QWB-SA were examined in relation to the CES-D the SRB, the CarerQol, and each other.
A total of 65 (63%) parents of children (≤17 years) responded. The mean SF-6D, HUI3, and QWB-SA scores were 0.81 (SD = 0.13), 0.84 (SD = 0.23), and 0.67 (SD = 0.14), respectively. The mean CES-D score was 13.3 (SD = 13.4) and 28.6% of the sample met a threshold for depressive symptoms (CES-D ≥ 16). The mean CarerQol-VAS and SRB scores were 7.5 (SD = 2.3) and 15.1 (SD = 23.5), respectively. The Spearman correlations (ρ) of the HUI3 and the SF-6D with the CES-D were similar (-0.81 and -0.76) while the ρ was lower (-0.57) for the QWB-SA. Preference-weighted scores of caregivers with CES-D scores ≥ 16 differed significantly for both the SF-6D and the HUI3, but not the QWB-SA. All three generic instruments showed moderate to strong relationships with the CarerQol.
The HUI3 and SF-6D were more sensitive predictors of depressive symptoms in this caregiver sample than was the QWB-SA. The CarerQol showed good construct validity and may be useful for measuring well-being effects associated with caregiving.
本研究旨在探讨三种通用工具对评估颅面畸形（CFM）患儿家庭照顾者健康状况偏好权重的敏感性。我们还检验了新的 CarerQol 工具测量照顾者负担和一般生活质量的结构效度。
通过阿肯色州生殖健康监测系统确定患有 CFM 的儿童的照顾者。通过邮寄调查包括 HUI3、SF-6D、QWB-SA 来测量健康相关的生活质量；CES-D 测量抑郁症状以及 SRB 量表和 CarerQol。HUI3、SF-6D 和 QWB-SA 与 CES-D、SRB、CarerQol 及其彼此之间进行了检验。
共有 65 名（63%）≤17 岁儿童的父母（父母）做出回应。SF-6D、HUI3 和 QWB-SA 的平均得分分别为 0.81（SD=0.13）、0.84（SD=0.23）和 0.67（SD=0.14）。CES-D 的平均得分是 13.3（SD=13.4），样本中有 28.6%的人达到了抑郁症状的阈值（CES-D≥16）。CarerQol-VAS 和 SRB 的平均得分分别为 7.5（SD=2.3）和 15.1（SD=23.5）。HUI3 和 SF-6D 与 CES-D 的斯皮尔曼相关系数（ρ）相似（-0.81 和-0.76），而 QWB-SA 的 ρ 较低（-0.57）。CES-D 得分≥16 的照顾者的偏好加权得分在 SF-6D 和 HUI3 上差异显著，但 QWB-SA 上则不然。这三种通用工具与 CarerQol 均表现出中度至高度的关系。
在这个照顾者样本中，HUI3 和 SF-6D 比 QWB-SA 更能敏感地预测抑郁症状。CarerQol 具有良好的结构效度，可能有助于测量与护理相关的幸福感影响。
