Salian Sowmya, Thakur Srinath, Kulkarni Sudhindra, LaTorre Guy
Department of Periodontics and Implantology, SDM College of Dental Sciences and Hospital, Dharwad, India.
J Clin Dent. 2010;21(3):82-7.
The primary aim of this study was to compare the in vivo efficacy and safety of dentifrices containing either 5% NovaMin or 5% potassium nitrate, and a non-desensitizing dentifrice, on dentin hypersensitivity in a four-week, double-blind clinical study among a population in south India. In addition, a companion scanning electron microscopy evaluation was performed to demonstrate whether or not the test products occlude open dentin tubules in vitro.
Thirty volunteers with tooth sensitivity were recruited, and a double-blind, randomized, parallel, controlled clinical trial was conducted in a hospital setting. Clinical evaluation for dentin hypersensitivity was done using tactile, air blast, and cold water methods. Following baseline measures, subjects were randomly divided into three groups and treated as follows: Group A--dentifrice containing 5% potassium nitrate; Group B--dentifrice containing 5% NovaMin; and Group C--dentifrice containing no desensitizing ingredients. Clinical evaluations were repeated after two and four weeks of product use.
Compared to baseline, there was a significant decrease in dentin hypersensitivity in Groups A and B following four weeks' use of the dentifrice containing 5% potassium nitrate and the dentifrice containing 5% calcium sodium phosphosilicate (NovaMin), respectively. There was a statistically greater reduction in hypersensitivity at both two and four weeks following use of the dentifrice containing NovaMin compared with the use of a non-desensitizing dentifrice, as well as the dentifrice containing potassium nitrate. Air and cold water scores were significantly lower following four weeks' use of the potassium nitrate dentifrice compared to the non-desensitizing dentifrice. Tubule occlusion was observed in the companion in vitro study following treatment with 5% NovaMin, but not after treatment with the 5% potassium nitrate or non-desensitizing dentifrices.
The results suggest that the dentifrice containing 5% NovaMin occludes dentin tubules, and provides rapid and significantly more relief from dentin hypersensitivity in four weeks compared to a dentifrice containing 5% potassium nitrate or a non-desensitizing dentifrice. All three dentifrices tested in this study were well-tolerated.
本研究的主要目的是在印度南部人群中进行的一项为期四周的双盲临床研究中，比较含5%诺瓦敏（NovaMin）或5%硝酸钾的牙膏以及一种非脱敏牙膏对牙本质过敏的体内疗效和安全性。此外，进行了一项配套的扫描电子显微镜评估，以证明测试产品在体外是否能封闭开放的牙本质小管。
招募了30名牙齿敏感的志愿者，并在医院环境中进行了一项双盲、随机、平行对照临床试验。使用触觉、气吹和冷水方法对牙本质过敏进行临床评估。在基线测量后，将受试者随机分为三组并进行如下治疗：A组——含5%硝酸钾的牙膏；B组——含5%诺瓦敏的牙膏；C组——不含脱敏成分的牙膏。在使用产品两周和四周后重复进行临床评估。
与基线相比，分别使用含5%硝酸钾的牙膏和含5%磷酸硅钙钠（诺瓦敏）的牙膏四周后，A组和B组的牙本质过敏显著降低。与使用非脱敏牙膏以及含硝酸钾的牙膏相比，使用含诺瓦敏的牙膏在两周和四周后超敏反应的降低在统计学上更显著。与非脱敏牙膏相比，使用含硝酸钾的牙膏四周后空气和冷水评分显著更低。在配套的体外研究中，用5%诺瓦敏处理后观察到小管封闭，但用5%硝酸钾或非脱敏牙膏处理后未观察到。
结果表明，含5%诺瓦敏的牙膏能封闭牙本质小管，与含5%硝酸钾的牙膏或非脱敏牙膏相比，在四周内能更快且显著地缓解牙本质过敏。本研究中测试的所有三种牙膏耐受性良好。
