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比较欧洲抗菌药物敏感性试验委员会和临床与实验室标准协会的肉汤微量稀释法,用于测试曲霉菌分离株的伊曲康唑、泊沙康唑和伏立康唑。

Comparison of the broth microdilution methods of the European Committee on Antimicrobial Susceptibility Testing and the Clinical and Laboratory Standards Institute for testing itraconazole, posaconazole, and voriconazole against Aspergillus isolates.

机构信息

Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA.

出版信息

J Clin Microbiol. 2011 Mar;49(3):1110-2. doi: 10.1128/JCM.02432-10. Epub 2011 Jan 5.

Abstract

We compared EUCAST and CLSI antifungal susceptibility testing methods for itraconazole, posaconazole, and voriconazole by testing 245 Aspergillus clinical isolates. The essential agreement (EA) between methods was excellent: 100% (itraconazole), 98.4% (posaconazole), and 99.6% (voriconazole) assessing EA at ±2 dilutions and 99.6% (itraconazole), 87.7% (posaconazole), and 96.3% (voriconazole) at ±1 dilution.

摘要

我们通过测试 245 株曲霉菌临床分离株,比较了 EUCAST 和 CLSI 的抗真菌药敏检测方法,用于检测伊曲康唑、泊沙康唑和伏立康唑。方法之间的基本一致率(EA)非常高:±2 倍稀释时,伊曲康唑为 100%(EA),泊沙康唑为 98.4%(EA),伏立康唑为 99.6%(EA);±1 倍稀释时,伊曲康唑为 99.6%(EA),泊沙康唑为 87.7%(EA),伏立康唑为 96.3%(EA)。

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