Department of Internal Medicine, University Hospital of Heraklion, Heraklion, Crete, Greece.
Eur J Clin Microbiol Infect Dis. 2011 May;30(5):653-60. doi: 10.1007/s10096-010-1135-4. Epub 2011 Jan 10.
We aimed to present our experience regarding infections caused by Serratia spp. in a region with relatively high antimicrobial resistance rates. We retrospectively reviewed the databases of the microbiological laboratory of the University Hospital of Heraklion, Crete (2/2004-12/2009). A total of 77 patients [67.5% men, mean age ± standard deviation (SD) = 56.9 ± 24.5 years) were identified; 37.7% were outpatients. Sixty-five (84.4%) of the 77 included patients had a Serratia marcescens isolate; the remaining 12 patients had a non-marcescens Serratia spp. The most frequently observed infections were respiratory tract infection (32.5%) and keratitis/endophthalmitis (20.8%). Seventy-three (94.9%) patients were cured. Four deaths were observed; three of them were considered as attributed to the Serratia infection. No difference was found regarding the characteristics and outcomes between patients with Serratia marcescens and non-marcescens infections. In addition, antipseudomonal penicillins and their combinations with beta-lactamase inhibitors, as well as carbapenemes, and fluoroquinolones exhibited high antimicrobial activity against both the tested Serratia marcescens and non-marcescens isolates. Our study adds useful information regarding the characteristics and outcomes of patients with Serratia infection, as well as the susceptibilities of the respective Serratia marcescens and non-marcescens isolates, in a region with relatively high levels of antimicrobial resistance.
我们旨在展示我们在一个具有相对较高抗生素耐药率的地区由粘质沙雷氏菌引起的感染经验。我们回顾性地审查了克里特岛伊拉克利翁大学医院微生物实验室的数据库（2004 年 2 月至 2009 年 12 月）。共确定了 77 例患者[67.5%为男性，平均年龄±标准差（SD）=56.9±24.5 岁]；37.7%为门诊患者。77 例纳入患者中 65 例（84.4%）为粘质沙雷氏菌分离株；其余 12 例患者为非粘质沙雷氏菌属的沙雷氏菌。最常见的感染是呼吸道感染（32.5%）和角膜炎/眼内炎（20.8%）。73 例（94.9%）患者治愈。观察到 4 例死亡；其中 3 例被认为与沙雷氏菌感染有关。粘质沙雷氏菌和非粘质沙雷氏菌感染患者的特征和结局无差异。此外，抗假单胞菌青霉素及其与β-内酰胺酶抑制剂的组合、碳青霉烯类和氟喹诺酮类对测试的粘质沙雷氏菌和非粘质沙雷氏菌分离株均具有较高的抗菌活性。我们的研究提供了有关在具有相对较高抗生素耐药率的地区粘质沙雷氏菌感染患者的特征和结局以及相应的粘质沙雷氏菌和非粘质沙雷氏菌分离株的药敏性的有用信息。
