Hawke S H, Hallinan J M, McLeod J G
Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia.
J Neurol Neurosurg Psychiatry. 1990 Sep;53(9):794-6. doi: 10.1136/jnnp.53.9.794.
Twenty one patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and five patients with chronic demyelinating polyneuropathy associated with benign monoclonal paraproteinaemia none of whom had signs or symptoms of central nervous system disease, had cranial magnetic resonance imaging (MRI) on a 1.5 Tesla unit. Areas of increased white matter signal intensity were seen in one of 10 patients aged less than 50 years and in five of 16 patients aged more than 50 years. In only two of the patients (8%), neither of whom had paraproteinaemia, did the appearance strongly suggest demyelination. The only clinical variable that predicted MRI changes was age (p less than 0.01).
21例慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）患者和5例与良性单克隆副蛋白血症相关的慢性脱髓鞘性多发性神经病患者，均无中枢神经系统疾病的体征或症状，在1.5特斯拉的设备上进行了头颅磁共振成像（MRI）检查。在10例年龄小于50岁的患者中有1例出现白质信号强度增加区域，在16例年龄大于50岁的患者中有5例出现该情况。仅2例患者（8%）的表现强烈提示脱髓鞘，这2例均无副蛋白血症。预测MRI改变的唯一临床变量是年龄（p<0.01）。
