Ormerod I E, Waddy H M, Kermode A G, Murray N M, Thomas P K
National Hospital for Neurology and Neurosurgery, London.
J Neurol Neurosurg Psychiatry. 1990 Sep;53(9):789-93. doi: 10.1136/jnnp.53.9.789.
In a consecutive series of 30 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) minor clinical evidence of CNS involvement was found in five. Cranial magnetic resonance imaging (MRI) was performed in 28 and revealed abnormalities consistent with demyelination in nine patients aged less than 50 years and abnormalities in five aged 50 years or over. Measurements of central motor conduction time (CMCT) were obtained in 18 and showed unilateral or bilateral abnormalities in six. It is concluded that subclinical evidence of central nervous system (CNS) involvement is common, at least in patients with CIDP in the United Kingdom, but that clinically evident signs of CNS disease are infrequent. The association of a multiple sclerosis-like syndrome with CIDP is rare.
在连续的30例慢性炎症性脱髓鞘性多发性神经病（CIDP）患者中，发现5例有中枢神经系统（CNS）受累的轻微临床证据。对28例患者进行了头颅磁共振成像（MRI）检查，结果显示，9例年龄小于50岁的患者有与脱髓鞘相符的异常，5例年龄50岁及以上的患者有异常。对18例患者进行了中枢运动传导时间（CMCT）测量，其中6例显示单侧或双侧异常。得出的结论是，中枢神经系统（CNS）受累的亚临床证据很常见，至少在英国的CIDP患者中如此，但CNS疾病的临床明显体征并不常见。CIDP与多发性硬化样综合征的关联很少见。
