Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, CEP 14404-600, Franca, SP, Brazil.
Molecules. 2011 Jan 18;16(1):762-73. doi: 10.3390/molecules16010762.
The in vitro schistosomicidal effects of the essential oil of Ageratum conyzoides L. (Ac-EO) against adult worms of Schistosoma mansoni is reported in this paper. Concerning this activity, Ac-EO was considered to be active, but less effective than the positive control (praziquantel, PZQ) in terms of separation of coupled pairs, mortality, decrease in motor activity, and tegumental alterations. However, Ac-EO caused an interesting dose-dependent reduction in the number of eggs of S. mansoni. Precocene I (74.30%) and (E)-caryophyllene (14.23%) were identified as the two major constituents of Ac-EO. These compounds were tested individually and were found to be much less effective than Ac-EO and PZQ. A mixture of the two major compounds in a ratio similar to that found in the Ac-EO was also less effective than Ac-EO, thus revealing that there are no synergistic effects between these components. These results suggest that the essential oil of A. conyzoides is very promising for the development of new schistosomicidal agents.
本文报道了苍耳草挥发油（Ac-EO）对曼氏血吸虫成虫的体外杀血吸虫效果。就这种活性而言，Ac-EO被认为是有效的，但与阳性对照（吡喹酮，PZQ）相比，在分离偶联对、死亡率、运动活性降低和表皮改变方面效果较差。然而，Ac-EO 导致曼氏血吸虫卵数量呈有趣的剂量依赖性减少。 Precocene I（74.30%）和（E）-丁香烯（14.23%）被鉴定为 Ac-EO 的两个主要成分。单独测试这些化合物，发现它们的效果远不如 Ac-EO 和 PZQ。两种主要化合物以类似于 Ac-EO 中发现的比例混合，其效果也不如 Ac-EO，从而表明这些成分之间没有协同作用。这些结果表明，苍耳草精油很有希望开发新的杀血吸虫药物。
