Croucher Institute for Environmental Sciences, and Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China.
Environ Int. 2011 Apr;37(3):637-43. doi: 10.1016/j.envint.2011.01.001. Epub 2011 Jan 21.
The mutagenicity and genotoxicity of workplace dust including commercial office, secondary school, shopping mall, hospital, electronics factory and manufacturing plant in Hong Kong and settled house dust from Hong Kong, Shenzhen and Guangzhou were measured. Results indicated that indoor dust contained both frameshift and base pair substitution mutagens. Dust from manufacturing plant showed highest mutagenic potency on TA98±S9 and TA100±S9 activation, whereas, electronics factory showed highest genotoxicity with and without S9 activation. TA100 (-S9) mutagenic potency was significantly correlated with genotoxicity expressed as SOSIP (-S9) of workplace dust (r(2)=0.37, p<0.01). The total PAHs concentration of settled house dust from PRD ranged from 1.63 to 29.2μg/g. Linear regression analyses indicated that the PAHs likely accounted for about 45% of the TA98 with S9 mutagenic activity of workplace dust. TA98 (-S9) mutagenicity (r(2)=0.27, p<0.05) and SOSIP (-S9) of house dust (r(2)=0.41, p<0.01) were both significantly correlated with the number of inhabitants in the house. To achieve a more accurate cancer risk assessment, the oral bioaccessibility of B(a)A, Chry, B(b+k)F, B(a)P, D(ah)A and I(cd)P in different dust ranging from 1.3% to 17% was taken into account. Risk assessments indicated that about 26% of house dust samples resulted in unacceptable cancer risk (>1×10(-6)) for preschool children.
研究了包括商业办公、中学、购物中心、医院、电子工厂和制造厂在内的香港工作场所灰尘以及香港、深圳和广州的积尘的致突变性和遗传毒性。结果表明，室内灰尘中含有移码和碱基替换诱变剂。来自制造厂的灰尘在 TA98±S9 和 TA100±S9 激活时表现出最高的致突变活力，而电子工厂在有或没有 S9 激活时表现出最高的遗传毒性。TA100(-S9)致突变活力与工作场所灰尘的 SOSIP(-S9)遗传毒性呈显著相关(r(2)=0.37，p<0.01)。珠三角地区积尘中的总多环芳烃浓度范围为 1.63 至 29.2μg/g。线性回归分析表明，多环芳烃可能占工作场所灰尘中 TA98 与 S9 致突变活性的 45%左右。TA98(-S9)致突变性(r(2)=0.27，p<0.05)和积尘的 SOSIP(-S9)(r(2)=0.41，p<0.01)均与房屋内居民人数呈显著相关。为了更准确地评估癌症风险，考虑了不同灰尘中 B(a)A、Chry、B(b+k)F、B(a)P、D(ah)A 和 I(cd)P 的口腔生物可利用性，范围为 1.3%至 17%。风险评估表明，约 26%的家庭灰尘样本对学龄前儿童造成不可接受的癌症风险(>1×10(-6))。
