Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 Apr;28(4):461-70. doi: 10.1080/19440049.2010.544678. Epub 2011 Jan 18.
Aflatoxins and fumonisins are ubiquitous foodborne toxicants and the co-occurrence of these mycotoxins in human foods represents a significant public health concern, which has been strongly associated with human aflatoxicosis, neural tube defects, as well as many types of primary cancers. In this study the co-contamination of aflatoxin B(1) (AFB(1)) and fumonisin B(1) (FB(1)) in food and human dietary exposure was investigated in residents of three different areas of China. A total of 209 food samples were measured for AFB(1) and FB(1). The median AFB(1) levels were 13.5, 2.3 and 1.3 µg kg(-1) and the median FB(1) levels were 2.6, 0.4 and 0.3 mg kg(-1) in corn samples collected from Huaian (a high-risk area for oesophageal cancer), Fusui (a high-risk area for liver cancer) and Huantai (a low-risk area for both oesophageal and liver cancers), respectively. The median level of AFB(1) in plant oil of Fusui was the highest (52.3 µg kg(-1)) among all food samples analysed. Co-contamination of these two mycotoxins was found in corn, rice and wheat flour. Based on measured food consumption data, the averaged daily dietary intake of AFB(1) was 0.397 µg (range = 0.269-1.218 µg) in residents of Huantai, 1.723 µg (0.224-49.772 µg) in Huaian, and 2.685 µg (1.006-14.534 µg) in Fusui. The averaged FB(1) daily dietary intake was 92.4 µg (range = 55.0-362.1 µg) for residents of Huantai, 460.0 µg (83.2-2894.5 µg) in Huaian, and 138.6 µg (30.0-10,541.6 µg) in Fusui. These data suggest that the co-exposure to AFB(1) and FB(1) in residents of rural China may contribute to the aetiology of human chronic diseases in high-risk areas.
黄曲霉毒素和伏马菌素是普遍存在的食源性有毒物质，这些真菌毒素在人类食物中的共同存在是一个重大的公共卫生问题，与人类黄曲霉毒素中毒、神经管缺陷以及许多类型的原发性癌症密切相关。在这项研究中，研究人员调查了中国三个不同地区居民的食物中黄曲霉毒素 B(1) (AFB(1))和伏马菌素 B(1) (FB(1))的共同污染情况以及人类饮食暴露情况。共检测了 209 个食品样本中的 AFB(1)和 FB(1)。在来自淮安（食管癌高发区）、扶绥（肝癌高发区）和桓台（食管癌和肝癌低发区）的玉米样本中，AFB(1)的中位数水平分别为 13.5、2.3 和 1.3μgkg(-1)，FB(1)的中位数水平分别为 2.6、0.4 和 0.3mgkg(-1)。在所分析的所有食品中，扶绥植物油中 AFB(1)的中位数水平最高（52.3μgkg(-1))。这两种真菌毒素在玉米、大米和小麦面粉中存在共同污染。根据所测食物消费数据，桓台居民的 AFB(1)平均日膳食摄入量为 0.397μg（范围为 0.269-1.218μg），淮安居民为 1.723μg（0.224-49.772μg），扶绥居民为 2.685μg（1.006-14.534μg）。桓台居民的 FB(1)平均日膳食摄入量为 92.4μg（范围为 55.0-362.1μg），淮安居民为 460.0μg（83.2-2894.5μg），扶绥居民为 138.6μg（30.0-10541.6μg）。这些数据表明，中国农村居民同时接触 AFB(1)和 FB(1)可能导致高危地区人类慢性病的病因。
