Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Clin Pharmacol Ther. 2011 Mar;89(3):460-3. doi: 10.1038/clpt.2010.254. Epub 2011 Jan 26.
Initial screening of medications for efficacy in treating drug dependence may be accomplished more efficiently by using novel approaches that combine the practical advantages of within-subject laboratory studies with the clinical validity provided by clinical trials. selection of functional gene variants associated with the pharmacokinetic or pharmacodynamic effects of a medication may aid this effort by controlling for individual variability as to clinical response or adverse effects; however, there are limitations to this approach, and these should be carefully considered.
通过采用新方法，将个体内实验室研究的实际优势与临床试验的临床有效性相结合，可能更有效地对药物的疗效进行初步筛选，这些新方法可能有助于这一工作。选择与药物的药代动力学或药效学效应相关的功能性基因变异，可以通过控制个体对临床反应或不良反应的变异性来辅助这一工作；然而，这种方法存在局限性，应该仔细考虑这些局限性。
