Department of Physiology, University of Tuebingen, Gmelinstr. 5, 72076, Tuebingen, Germany.
Psychopharmacology (Berl). 2011 Jun;215(4):733-7. doi: 10.1007/s00213-011-2175-x. Epub 2011 Jan 29.
Several studies suggest an association between hypovitaminosis D and basic and executive cognitive functions, depression, bipolar disorder, and schizophrenia. A recent study confirms neophobic responses in vitamin D receptor mutant mice. We explored whether the plasma levels of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)), the active form of vitamin D, are correlated with basic personality traits.
A total of 206 healthy unrelated volunteers (108 male, 98 female, age 31 ± 13 years) completed the German version of the NEO Five-Factor Inventory (NEO-FFI), which allows reliable and valid assessment of personality along the dimensions neuroticism, extraversion, openness to new experiences, agreeableness and conscientiousness.
We found a significant correlation between 1,25(OH)(2)D(3) concentration and the factor extraversion (n = 206, r = 0.202, p = 0.004) and the factor openness (n = 206, r = 0.148, p = 0.034).
The possible mechanisms by which 1,25(OH)(2)D(3) acts on the brain might include Ca(2+) signaling, buffering antioxidant, and anti-inflammatory defenses against vascular injury, stimulating neurotrophins and improving metabolic and cardiovascular function. In conclusion, we suggest that 1,25(OH)(2)D(3) might influence personality traits, promoting extrovert and open behavior.
几项研究表明，维生素 D 缺乏症与基础和执行认知功能、抑郁症、双相情感障碍和精神分裂症之间存在关联。最近的一项研究证实维生素 D 受体突变小鼠存在新事物恐惧症反应。我们探讨了血浆中 1,25-二羟维生素 D（1,25(OH)(2)D(3)）的水平，即维生素 D 的活性形式，是否与基本人格特质相关。
共有 206 名健康无血缘关系的志愿者（108 名男性，98 名女性，年龄 31±13 岁）完成了德国版的五因素人格问卷（NEO-FFI），该问卷可对神经质、外向性、开放性、宜人性和尽责性等维度进行可靠和有效的人格评估。
我们发现 1,25(OH)(2)D(3)浓度与外向性因子（n=206，r=0.202，p=0.004）和开放性因子（n=206，r=0.148，p=0.034）之间存在显著相关性。
1,25(OH)(2)D(3)作用于大脑的可能机制包括 Ca(2+)信号、缓冲抗氧化剂和血管损伤的抗炎防御、刺激神经营养因子和改善代谢及心血管功能。总之，我们认为 1,25(OH)(2)D(3)可能影响人格特质，促进外向和开放的行为。
