Medical Research Council Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
PLoS One. 2012;7(7):e40097. doi: 10.1371/journal.pone.0040097. Epub 2012 Jul 10.
Higher serum concentrations of 25-hydroxyvitamin D (25(OH)D), an indicator of vitamin D synthesis and intake, have been associated with better mental health and cognitive function. Concentrations of 1,25-dihydroxyvitamin D(3) (the active vitamin D(3) metabolite) have been associated with openness and extrovert behaviour, but 25(OH)D concentrations have not been associated with behavioural problems in humans.
We investigated the prospective association between the different forms of 25(OH)D - 25(OH)D(3) and 25(OH)D(2)- and childhood behavioural problems in Avon Longitudinal Study of Parents and Children (ALSPAC). Serum 25(OH)D(3) and 25(OH)D(2) concentrations were assessed at mean age 9.9 years. Incident behavioural problems were assessed with Strengths and Difficulties Questionnaire (SDQ; emotional symptoms, conduct problems, hyperactivity-inattention problems, peer relationship problems and pro-social behaviour subscales and total difficulties score) at mean age 11.7. Sample sizes varied between 2413-2666 depending on the outcome.
Higher 25(OH)D(3) concentrations were weakly associated with lower risk of prosocial problems (fully adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.74, 0.98)). Serum 25(OH)D(3) or 25(OH)D(2) concentrations were not associated with other subscales of SDQ or total difficulties score after adjusting for concfounders and other measured analytes related to vitamin D.
Our findings do not support the hypothesis that 25-hydroxyvitamin D status in childhood has important influences on behavioural traits in humans.
血清中 25-羟维生素 D（25（OH）D）的浓度较高，这是维生素 D 合成和摄入的指标，与更好的心理健康和认知功能有关。1,25-二羟维生素 D（3）（活性维生素 D（3）代谢物）的浓度与开放性和外向行为有关，但 25（OH）D 浓度与人类的行为问题无关。
我们在阿冯纵向研究父母和儿童（ALSPAC）中调查了不同形式的 25（OH）D-25（OH）D（3）和 25（OH）D（2）与儿童行为问题的前瞻性关联。血清 25（OH）D（3）和 25（OH）D（2）浓度在平均年龄 9.9 岁时进行评估。使用长处与困难问卷（SDQ；情绪症状、行为问题、多动-注意力问题、同伴关系问题和亲社会行为分量表以及总困难评分）在平均年龄 11.7 岁时评估新发生的行为问题。根据结果，样本量在 2413-2666 之间变化。
较高的 25（OH）D（3）浓度与较低的亲社会问题风险相关（完全调整后的优势比：OR（95%置信区间：CI）0.85（0.74，0.98））。在调整混杂因素和与维生素 D 相关的其他测量分析物后，血清 25（OH）D（3）或 25（OH）D（2）浓度与 SDQ 的其他分量表或总困难评分无关。
我们的研究结果不支持这样的假设，即儿童期 25-羟维生素 D 状态对人类的行为特征有重要影响。
