Haverford College, 370 Lancaster Ave., Haverford, PA, 19041, United States.
Brain Lang. 2011 Mar;116(3):105-15. doi: 10.1016/j.bandl.2010.12.005. Epub 2011 Jan 28.
This study was designed to characterize the brain system that monitors speech in people who stutter and matched controls. We measured two electrophysiological peaks associated with action-monitoring: the error-related negativity (ERN) and the error positivity (Pe). Both the ERN and Pe were reliably observed after errors in a rhyming task and a nonverbal flanker task, replicating previous reports of a language-monitoring ERN and demonstrating that the Pe can also be elicited by phonological errors. In the rhyming task, stutterers showed a heightened ERN peak regardless of whether they actually committed an error. Similar results, though only marginally significant, were obtained from the flanker task. These results support the vicious cycle hypothesis, which posits that stuttering results from over-monitoring the speech plan. The elevation of the ERN in stutterers and the similarity of the results between the flanker and rhyming tasks implies that speech-monitoring may rely on the same neural substrate as action-monitoring.
本研究旨在描述口吃者和匹配对照组中监测言语的大脑系统。我们测量了与动作监测相关的两个电生理峰值：错误相关负波（ERN）和错误正波（Pe）。在押韵任务和非言语侧翼任务中，均可靠地观察到 ERN 和 Pe 在错误之后出现，这复制了先前关于语言监测 ERN 的报告，并表明 Pe 也可以由语音错误引起。在押韵任务中，口吃者表现出更高的 ERN 峰值，无论他们是否真的犯了错误。侧翼任务的结果也相似，但仅略微显著。这些结果支持恶性循环假说，该假说认为口吃是由于过度监测言语计划所致。口吃者ERN 的升高以及侧翼和押韵任务之间结果的相似性表明，言语监测可能依赖于与动作监测相同的神经基质。
