Department of Biomedical Science, Universiti Putra Malaysia, Selangor, Malaysia.
Biol Res Nurs. 2012 Jan;14(1):90-7. doi: 10.1177/1099800410395378. Epub 2011 Jan 28.
Ficus deltoidea (Family Moraceae) leaves have been used traditionally by the Malays to treat ailments such as wounds, sores, and rheumatism. The aim of the present study was to determine the anti-inflammatory activity of the aqueous extract of F. deltoidea leaf (FDA) using acute and chronic inflammatory models. FDA, in the doses of 30, 100, and 300 mg/kg, was administered intraperitoneally in rats (n = 6) before the animals were subjected to the carrageenan-induced paw edema test, cotton pellet-induced granuloma test, and formalin test. The first two tests represent acute and chronic models of inflammation, respectively. The first and second phases of the formalin test represent neurogenic pain and inflammatory-mediated pain, respectively; thus, only the second phase was measured in the present study. Results showed that FDA exerted significant (p < .05) anti-inflammatory activity in all assays, with dose-response effects seen in the paw edema and formalin tests. In conclusion, the leaf of F. deltoidea possesses anti-inflammatory activity against acute and chronic inflammatory responses and against pain-associated inflammatory response. These findings justify the traditional uses of F. deltoidea leaves for treatment of inflammatory-mediated ailments.
榕属（桑科）叶在过去被马来人用于治疗各种疾病，如创伤、溃疡和风湿病。本研究旨在通过急性和慢性炎症模型来确定榕树叶水提物（FDA）的抗炎活性。FDA 以 30、100 和 300mg/kg 的剂量腹腔内给药，然后将动物置于角叉菜胶诱导的爪肿胀试验、棉纤维球诱导的肉芽肿试验和福氏佐剂诱导的福尔马林试验中。前两个试验分别代表急性和慢性炎症模型。福氏佐剂试验的第一和第二阶段分别代表神经源性疼痛和炎症介导的疼痛，因此本研究仅测量了第二阶段。结果表明，FDA 在所有试验中均表现出显著的抗炎活性（p<.05），并且在爪肿胀和福氏佐剂试验中均存在剂量反应。综上所述，榕树叶具有抗炎活性，可对抗急性和慢性炎症反应以及与疼痛相关的炎症反应。这些发现证明了榕树叶用于治疗炎症性疾病的传统用途。
