激活大鼠回肠制动的脂质物质的特性
Characteristics of lipid substances activating the ileal brake in the rat.
作者信息
Brown N J, Read N W, Richardson A, Rumsey R D, Bogentoft C
机构信息
Sub-department of Gastrointestinal Physiology and Nutrition, University of Sheffield, Western Bank.
出版信息
Gut. 1990 Oct;31(10):1126-9. doi: 10.1136/gut.31.10.1126.
Studies were carried out in 36 adult male rats to determine the characteristics of lipid substances which, after infusion into the ileum, slow the stomach to caecum transit time of the head of a bean meal in the rat. Stomach to caecum transit time was measured by environmental hydrogen analysis. Ileal infusion of a range of free fatty acids including petroselinic, oleic, myristoleic, erucic, linoleic, and linolenic all significantly slowed stomach to caecum transit time, as did the detergents (sodium bis (2-ethyl hexyl) sulphosuccinate and sodium linoleyl sulphate), the triglyceride corn oil, and the phospholipid lecithin. Although the lipid soluble deconjugated bile acid deoxycholic acid slowed stomach to caecum transit time, the water soluble conjugated bile acid taurocholic acid accelerated it. Infusion of the lipid alcohol oleyl alcohol and the calcium chelating agent disodium edetate (EDTA) into the ileum did not delay the passage of the meal through the stomach and small intestine. The diversity of lipid substances activating the ileal brake suggest a nonspecific effect by lipid soluble substances that can penetrate cell membranes. The lack of effect of EDTA suggested that calcium binding was not important.
对36只成年雄性大鼠进行了研究，以确定脂质物质的特性，这些脂质物质在注入回肠后，会减缓大鼠豆粕头部从胃到盲肠的转运时间。通过环境氢气分析来测量胃到盲肠的转运时间。回肠注入一系列游离脂肪酸，包括岩芹酸、油酸、肉豆蔻油酸、芥酸、亚油酸和亚麻酸，以及去污剂（二（2-乙基己基）磺基琥珀酸钠和亚油酸钠硫酸酯）、甘油三酯玉米油和磷脂卵磷脂，均显著减缓了胃到盲肠的转运时间。尽管脂溶性去结合胆汁酸脱氧胆酸减缓了胃到盲肠的转运时间，但水溶性结合胆汁酸牛磺胆酸却加速了这一过程。将脂醇油醇和钙螯合剂乙二胺四乙酸二钠（EDTA）注入回肠，并未延迟食物通过胃和小肠的时间。激活回肠制动的脂质物质的多样性表明，能够穿透细胞膜的脂溶性物质具有非特异性作用。EDTA没有作用表明钙结合并不重要。
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