Richardson A, Delbridge A T, Brown N J, Rumsey R D, Read N W
Sub-Department of Gastrointestinal, Physiology and Nutrition, University of Sheffield.
Gut. 1991 Mar;32(3):266-9. doi: 10.1136/gut.32.3.266.
We have previously shown that infusion of triglycerides and long chain fatty acids into the ileum of humans and rats delays small bowel transit time. The present studies have investigated the effect on the stomach to caecum transit time of a baked bean meal of the ileal infusion of 20 mM, 50 mM, and 100 mM acetic, butyric, hexenoic, and caprylic acids in rats. After an 18 hour fast either a control or a short chain fatty acid (SCFA) solution (pH 6.5) was infused into the ileum for 30 minutes (0.3 ml/hour). A test meal was given by gavage and the infusion continued for a further 150 minutes. The arrival of the meal in the colon was signalled by a rise in the exhaled hydrogen concentration. Acetic acid (20 mM, 50 mM, 100 mM), butyric acid (100 mM), and caprylic acid (100 mM) produced a significant acceleration of transit which was inversely proportional to SCFA chain length. In a separate experiment, infusion of 100 mM acetic acid, the most potent SCFA, into an isolated ileal Thirty-Vella loop failed to accelerate transit of the test meal. Our results suggest that SCFAs accelerate transit via a local enteric reflex.
我们之前已经表明，向人类和大鼠的回肠输注甘油三酯和长链脂肪酸会延迟小肠转运时间。本研究调查了在大鼠中，向回肠输注20 mM、50 mM和100 mM的乙酸、丁酸、己烯酸和辛酸对胃至盲肠转运时间的影响，这些酸来自一份烘豆餐。禁食18小时后，将对照溶液或短链脂肪酸（SCFA）溶液（pH 6.5）以0.3毫升/小时的速度向回肠输注30分钟。通过灌胃给予试验餐，并继续输注150分钟。呼出氢气浓度升高表明餐食到达结肠。乙酸（20 mM、50 mM、100 mM）、丁酸（100 mM）和辛酸（100 mM）显著加速了转运，且与SCFA链长成反比。在另一项实验中，将最有效的SCFA即100 mM乙酸输注到一个孤立的回肠Thirty-Vella肠袢中，未能加速试验餐的转运。我们的结果表明，SCFAs通过局部肠反射加速转运。
