Department of Endocrinology and Diabetology, University Clinic Saint-Luc, Université Catholique de Louvain (UCL), Avenue Hippocrate 54/UCL 5474, B-1200 Brussels, Belgium.
Med Clin North Am. 2011 Mar;95(2):289-97, vii. doi: 10.1016/j.mcna.2010.11.002.
Diabetes evolves through prediabetes, defined as impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). Subjects with IFG/IGT have an increased risk of developing diabetes and a higher prevalence of cardiovascular disease than normoglycemic individuals. However, there is considerable evidence that glucose levels lower than those meeting the current definition of prediabetes may also be associated with similar concerns, particularly in high-risk individuals in accordance with a continuous glycemic risk perspective. Therefore, an absolute definition of prediabetes may underestimate the implications and vastness of this disorder. Research should focus on these aspects to minimize the risk of developing a preventable condition.
糖尿病的发展过程经历了前驱糖尿病阶段，其定义为空腹血糖受损（IFG）和/或葡萄糖耐量受损（IGT）。IFG/IGT 患者发生糖尿病的风险增加，且心血管疾病的患病率高于血糖正常者。然而，有大量证据表明，目前定义的前驱糖尿病血糖水平以下也可能与类似问题相关，尤其是根据连续血糖风险视角来看，高危个体中更是如此。因此，前驱糖尿病的绝对定义可能低估了这种疾病的影响和广泛性。研究应重点关注这些方面，以最大限度地降低发生可预防疾病的风险。
