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携带 qnrS1 的质粒在医院和社区共生肠杆菌中的表型和基因型特征差异。

Differential phenotypic and genotypic characteristics of qnrS1-harboring plasmids carried by hospital and community commensal enterobacteria.

机构信息

The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

出版信息

Antimicrob Agents Chemother. 2011 Apr;55(4):1798-802. doi: 10.1128/AAC.01200-10. Epub 2011 Jan 31.

DOI:10.1128/AAC.01200-10
PMID:21282449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3067134/
Abstract

The qnrS1 gene induces reduced susceptibility to fluoroquinolones in enterobacteria. We investigated the structure, antimicrobial susceptibility phenotype, and antimicrobial resistance gene characteristics of qnrS1 plasmids from hospitalized patients and community controls in southern Vietnam. We found that the antimicrobial susceptibilities, resistance gene characteristics, and plasmid structures of qnrS1 plasmids from the hospital differed from those from the community. Our data imply that the characteristics of the two plasmid groups are indicative of distinct selective pressures in the differing environments.

摘要

qnrS1 基因可导致肠杆菌对氟喹诺酮类药物的敏感性降低。我们研究了来自越南南部住院患者和社区对照者的 qnrS1 质粒的结构、抗菌药敏表型和抗菌耐药基因特征。我们发现医院来源的 qnrS1 质粒的药敏、耐药基因特征和质粒结构与社区来源的不同。我们的数据表明，两组质粒的特征表明在不同环境中有不同的选择压力。

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