Can Fam Physician. 1984 Jan;30:81-4.
In this study, 232 Canadian family physicians recorded suspected adverse drug reactions (SADRs) in their practices for five months. Patients' age and sex, the drug(s) implicated, type of reaction and any disability were recorded on a card and sent to a central coordinating office each week. The number of SADRs in clinical practice seems to be small. An estimated 300,000 patients were involved in the study, and a total of 314 suspected adverse drug reactions in 314 patients were reported. A proposal is made for a surveillance system for new drugs. Family physicians would monitor all patients taking a drug or group of drugs and matched controls. The status of patients and controls would be recorded regularly and any SADRs reported to a central coordinating centre.
在这项研究中，232 名加拿大家庭医生在他们的诊所中记录了五个月的疑似药物不良反应（SADRs）。患者的年龄和性别、涉及的药物、反应类型以及任何残疾情况都记录在一张卡片上，并每周发送到一个中央协调办公室。临床实践中的 SADR 数量似乎很小。据估计，该研究涉及 30 万名患者，共报告了 314 名患者中的 314 例疑似药物不良反应。提出了一个新药监测系统的建议。家庭医生将监测所有服用药物或药物组的患者和匹配的对照组。定期记录患者和对照组的情况，并向中央协调中心报告任何 SADR。
