Harwood Naomi E, Batista Facundo D
Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK 44 Lincoln's Inn Fields, London WC2A 3LY UK.
F1000 Biol Rep. 2010 Dec 17;2:87. doi: 10.3410/B2-87.
B cells are capable of mounting responses to a bewildering range of potentially pathogenic antigens through the production of high-affinity antibodies and the establishment of immunological memory. Thus, regulated B-cell activation is critical for protection against a variety of bacterial and viral infections, as well as cancers. Here, we discuss a number of recent imaging studies that have provided new insights into the variety of mechanisms by which B-cell activation is initiated in the lymph node in vivo.
B细胞能够通过产生高亲和力抗体和建立免疫记忆，对一系列令人眼花缭乱的潜在致病抗原产生反应。因此，受调控的B细胞激活对于抵御各种细菌和病毒感染以及癌症至关重要。在这里，我们讨论了一些最近的成像研究，这些研究为体内淋巴结中启动B细胞激活的多种机制提供了新的见解。
