Department of Pharmacognosy, Faculty of Pharmacy, Beni-Sueif University, Beni-Sueif, Egypt.
Pharm Biol. 2011 Apr;49(4):392-5. doi: 10.3109/13880209.2010.518971. Epub 2011 Feb 2.
Tamarix nilotica (Ehrenb.) Bunge (Tamaricaceae) is used in the Egyptian traditional medicine as an antiseptic agent. This plant has been known since pharaonic times and has been mentioned in medical papyri to expel fever, relieve headache, to draw out inflammation, and as an aphrodisiac. No scientific study is available about the biological effect of this plant.
This study aimed to evaluate the hydro-alcoholic extract (80%) of T. nilotica flowers for hepatoprotective and antioxidant activities.
Hepatoprotective activity was assessed using carbon tetrachloride-induced hepatic injury in rats by monitoring biochemical parameters. Antioxidant activity was evaluated in alloxan-induced diabetic rats. Biochemical markers of hepatic damage such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), and tissue glutathione were determined in all groups.
Carbon tetrachloride (5 mL/kg body weight) enhanced the SGOT, SGPT, and ALP levels. There was a marked reduction in tissue glutathione level in diabetic rats. The hydro-alcoholic extract of T. nilotica (100 mg/kg body weight) ameliorated the adverse effects of carbon tetrachloride and returned the altered levels of biochemical markers near to the normal levels.
柽柳（Ehrenb.）Bunge（柽柳科）在埃及传统医学中被用作防腐剂。这种植物自法老时代以来就为人所知，并在医学纸莎草中被提及，用于退热、缓解头痛、消肿和作为壮阳药。关于这种植物的生物学效应尚无科学研究。
本研究旨在评估柽柳花的水醇提取物（80%）的保肝和抗氧化活性。
通过监测生化参数，用四氯化碳诱导大鼠肝损伤来评估保肝活性。在链脲佐菌素诱导的糖尿病大鼠中评估抗氧化活性。所有组均测定血清谷氨酸草酰乙酸转氨酶（SGOT）、血清谷氨酸丙酮酸转氨酶（SGPT）、碱性磷酸酶（ALP）和组织谷胱甘肽等肝损伤的生化标志物。
五氯乙烷（5mL/kg 体重）可增强 SGOT、SGPT 和 ALP 水平。糖尿病大鼠组织谷胱甘肽水平明显降低。柽柳花的水醇提取物（100mg/kg 体重）减轻了五氯乙烷的不良影响，使生化标志物的改变水平接近正常水平。
