Mavrogenis Andreas F, Papagelopoulos Panayiotis J, Romantini Matteo, Angelini Andrea, Ruggieri Pietro
Istituto Ortopedico Rizzoli, Department of Orthopaedics, University of Bologna, Bologna, Italy.
J Long Term Eff Med Implants. 2010;20(1):1-12. doi: 10.1615/jlongtermeffmedimplants.v20.i1.10.
With recent advances in medical and orthopedic oncology, radiation therapy and single- or multiple-agent perioperative chemotherapy are currently applied as an essential part of the multidisciplinary treatment to improve disease-free and overall survival of patients with primary and metastatic bone and soft tissue tumors. However, these treatments have led to unwanted complications. A better understanding of the effects of various antineoplastic agents on bone, soft tissue, and organs may provide the basis for the more efficacious use of antiproliferative drugs when fracture healing or allograft incorporation is required. This knowledge may also provide a rationale for concurrent treatment with drugs that protect against or compensate for adverse effects in osseous repair resulting from chemotherapy.
随着医学和骨肿瘤学的最新进展，放射治疗以及单药或多药围手术期化疗目前已作为多学科治疗的重要组成部分应用于临床，以提高原发性和转移性骨与软组织肿瘤患者的无病生存期和总生存期。然而，这些治疗引发了不良并发症。更好地了解各种抗肿瘤药物对骨、软组织和器官的影响，可能为在需要骨折愈合或同种异体骨植入时更有效地使用抗增殖药物提供依据。这一知识也可为同时使用预防或补偿化疗对骨修复产生的不良反应的药物提供理论基础。
