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Ann Surg. 1975 Aug;182(2):121-3. doi: 10.1097/00000658-197508000-00006.
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Inhibition of gastric secretion by atropine in conscious rats.阿托品对清醒大鼠胃液分泌的抑制作用。
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引用本文的文献

1
Potentiation of gastrin and histamine stimulated acid secretion in Heidenhain pouches by distention--an atropine-resistant mechanism.扩张对海登海因小胃中胃泌素和组胺刺激的胃酸分泌的增强作用——一种抗阿托品机制。
Pflugers Arch. 1980 Jul;386(1):53-7. doi: 10.1007/BF00584187.
2
Does pentagastrin supress secretin induced pepsin secretion in Heidenhain pouch dogs?五肽胃泌素是否会抑制海登海因小胃犬中促胰液素诱导的胃蛋白酶分泌？
Experientia. 1975 Jul 15;31(7):821-2. doi: 10.1007/BF01938485.
3
The effect of atropine on acid secretion stimulated by acetylcholine, histamine and gastrin in the isolated whole stomach of the rat.阿托品对大鼠离体全胃中乙酰胆碱、组胺和胃泌素刺激的胃酸分泌的影响。
Br J Pharmacol. 1977 Oct;61(2):279-84. doi: 10.1111/j.1476-5381.1977.tb08416.x.
4
Effect of atropine and proximal gastric vagotomy on the acid response to fundic distension in man.阿托品和近端胃迷走神经切断术对人体胃底扩张酸反应的影响。
Gut. 1977 Apr;18(4):303-10. doi: 10.1136/gut.18.4.303.
5
Evidence for antral inhibition of pentagastrin from experiments using mucosal cooling.使用黏膜冷却实验得出的胃窦对五肽胃泌素抑制作用的证据。
J Physiol. 1977 Aug;270(1):37-50. doi: 10.1113/jphysiol.1977.sp011937.

本文引用的文献

1
The inhibition of pepsin output in separated gastric pouches in dogs following feeding, and its correlation with motility changes.喂食后犬离体胃袋中胃蛋白酶分泌的抑制及其与运动变化的相关性。
Gastroenterology. 1959 Aug;37:169-81.
2
Vago-vagal reflex effects on gastric and pancreatic secretion and gastrointestinal motility.迷走-迷走反射对胃和胰腺分泌以及胃肠运动的影响。
J Physiol. 1959 Oct;148(2):417-36. doi: 10.1113/jphysiol.1959.sp006297.
3
Stimulation of secretion of acid by distention of denervated fundic pouches in dogs.狗去神经支配胃底袋扩张对胃酸分泌的刺激作用。
Gastroenterology. 1961 Oct;41:385-90.
4
Secretion of acid and pepsin in response to distention of vagally innervated fundic gland area in dogs.犬迷走神经支配的胃底腺区扩张时酸和胃蛋白酶的分泌
Gastroenterology. 1962 Jun;42:718-21.
5
Influence of the antrum on the acid response to distension of the body of the stomach in dogs.胃窦对犬胃体扩张酸反应的影响。
Can J Physiol Pharmacol. 1970 Oct;48(10):661-9. doi: 10.1139/y70-097.
6
Gastric and pancreatic secretion in response to gastric distention in dogs.犬胃扩张时的胃和胰腺分泌
Gastroenterology. 1969 Sep;57(3):300-10.
7
Effects of gastrin and histamine on vagally induced acid and pepsin secretion in antrectomized dogs.胃泌素和组胺对胃窦切除犬迷走神经诱导的胃酸和胃蛋白酶分泌的影响。
Acta Physiol Scand. 1968 Apr;72(4):492-7. doi: 10.1111/j.1748-1716.1968.tb03873.x.
8
Effect of ganglionic and muscarinic blockade on mechanism of pepsin-secretion stimulation.神经节和毒蕈碱阻断对胃蛋白酶分泌刺激机制的影响。
Am J Physiol. 1974 Nov;227(5):1178-80. doi: 10.1152/ajplegacy.1974.227.5.1178.

海登海因小胃扩张作为胃酸和胃蛋白酶分泌的刺激因素。

Heidenhain pouch distension as a stimulus for acid and pepsin secretion.

作者信息

Magee D F, Hu C Y

出版信息

Ann Surg. 1975 Aug;182(2):121-3. doi: 10.1097/00000658-197508000-00006.

DOI:10.1097/00000658-197508000-00006
PMID:1108812
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1343828/
Abstract

Heidenhain pouches, in dogs with simple gastric fistulae, were distended with saline (30, 60 and 90 ml). Pouch acid and pepsin increased linearly with increasing saline volume. Additional pentagastrin augmented the acid but antagonized the pepsin responses. Atropine depressed both the acid and pepsin responses to distention. Ganglionic blockade and local anesthetization of the secretory mucosa also depressed the acid but spared the pepsin response.

摘要

在患有单纯胃瘘的狗身上，海登海因袋用生理盐水（30、60和90毫升）扩张。袋内的胃酸和胃蛋白酶随着生理盐水体积的增加呈线性增加。额外的五肽胃泌素增加了胃酸，但拮抗了胃蛋白酶的反应。阿托品抑制了胃酸和胃蛋白酶对扩张的反应。神经节阻断和分泌性黏膜的局部麻醉也抑制了胃酸，但保留了胃蛋白酶的反应。