Division of Allergy, Asthma and Clinical Immunology, Department of Internal Medicine, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Korea.
J Korean Med Sci. 2011 Feb;26(2):301-3. doi: 10.3346/jkms.2011.26.2.301. Epub 2011 Jan 24.
Although drug fever may develop after administration of the drug by various routes, it has not been reported with antibiotic-loaded bone cement. Here, a case of drug fever induced by piperacillin/tazobactam loaded into bone cement is reported. A 72-yr-old woman presented with fever that developed two weeks after insertion of bone cement loaded with antibiotics including piperacillin/tazobactam into the knee joint for infectious arthritis. The fever was associated with a skin rash and blood eosinophilia. The work-up of the fever excluded several causes. Drug provocation test demonstrated that the piperacillin/tazobactam, which had been loaded in the bone cement, was the cause of the fever. The findings of this case suggest that drug fever can be induced by any drug placed and released continuously within the body. Therefore, the evaluation for possible drug fever should include all drugs the patient has been exposed to regardless of the route of administration.
虽然药物热可在各种途径给药后发生，但尚未见抗生素骨水泥引起的药物热报道。本文报告 1 例哌拉西林/他唑巴坦骨水泥植入后引起的药物热。1 例 72 岁女性，因感染性关节炎将包含哌拉西林/他唑巴坦的抗生素骨水泥植入膝关节后 2 周出现发热。发热时伴有皮疹和血嗜酸性粒细胞增多。发热病因检查排除了其他原因。药物激发试验显示，在骨水泥中释放的哌拉西林/他唑巴坦是引起发热的原因。该病例提示任何在体内持续释放的药物都可引起药物热。因此，对可能的药物热的评估应包括患者接触的所有药物，而不考虑给药途径。
