编码区：被忽视的转录后密码子。
Coding region: the neglected post-transcriptional code.
机构信息
Laboratory of Cellular and Molecular Biology, NIA-IRP, NIH, Baltimore, MD, USA.
出版信息
RNA Biol. 2011 Jan-Feb;8(1):44-8. doi: 10.4161/rna.8.1.13863. Epub 2011 Jan 1.
Abstract
The control of mammalian mRNA turnover and translation has been linked almost exclusively to specific cis-elements within the 5'- and 3'-untranslated regions (UTRs) of the mature mRNA. However, instances of regulated turnover and translation via cis-elements within the coding region (CR) of mRNAs are accumulating. Here, we describe the regulation of post-transcriptional fate through trans-binding factors (RNA-binding proteins and microRNAs) that function via CR sequences. We discuss how the CR enriches the post-transcriptional control of gene expression, and predict that new high-throughput technologies will enable a more mainstream study of CR-governed gene regulation.
摘要
哺乳动物 mRNA 周转率和翻译的控制几乎完全与成熟 mRNA 的 5' 和 3'非翻译区 (UTR) 内的特定顺式元件相关。然而，通过 mRNA 编码区 (CR) 内的顺式元件进行调控的周转率和翻译的实例正在增加。在这里，我们描述了通过在 CR 序列上发挥作用的反式结合因子（RNA 结合蛋白和 microRNAs）来调节转录后命运。我们讨论了 CR 如何丰富基因表达的转录后调控，并预测新的高通量技术将使 CR 控制的基因调控的研究更为主流。
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