Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Traffic. 2011 May;12(5):535-42. doi: 10.1111/j.1600-0854.2011.01171.x. Epub 2011 Feb 25.
The signal recognition particle (SRP) is a key component of the cellular machinery that couples the ongoing synthesis of proteins to their proper localization, and has often served as a paradigm for understanding the molecular basis of protein localization within the cell. The SRP pathway exemplifies several key molecular events required for protein targeting to cellular membranes: the specific recognition of signal sequences on cargo proteins, the efficient delivery of cargo to the target membrane, the productive unloading of cargo to the translocation machinery and the precise spatial and temporal coordination of these molecular events. Here we highlight recent advances in our understanding of the molecular mechanisms underlying this pathway, and discuss new questions raised by these findings.
信号识别颗粒（SRP）是细胞机制的关键组成部分，它将蛋白质的持续合成与它们的正确定位联系起来，并且经常作为理解蛋白质在细胞内定位的分子基础的范例。SRP 途径体现了蛋白质靶向细胞膜所需的几个关键分子事件：对货物蛋白上信号序列的特异性识别、将货物高效递送至靶膜、将货物有效卸至转运机制以及这些分子事件的精确时空协调。在这里，我们强调了我们对该途径的分子机制的理解的最新进展，并讨论了这些发现提出的新问题。
