Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Am J Trop Med Hyg. 2011 Feb;84(2):229-33. doi: 10.4269/ajtmh.2011.10-0024.
Reports on the clinical entity of hemorrhagic fever with renal syndrome (HFRS) have focused on acute renal failure. Data on the extrarenal manifestations are limited primarily to case reports. In this study, protean extrarenal manifestations involving the major organs occurred in one-third of patients with HFRS during various stages (i.e., febrile phase through diuretic phase). Pancreatobiliary manifestations and major bleeding occurred in 11% and 10% of patients, respectively. Cardiovascular and central nervous system manifestations developed during the febrile or oliguric phase, whereas pancreatobiliary manifestations and major bleeding were detected even in the diuretic phase. Thus, close monitoring of and additional knowledge about various extrarenal manifestations are needed.
有关肾综合征出血热（HFRS）临床实体的报告主要集中在急性肾衰竭上。关于肾外表现的数据主要限于病例报告。在这项研究中，三分之一的 HFRS 患者在不同阶段（即发热期至利尿期）出现涉及主要器官的多种肾外表现。分别有 11%和 10%的患者出现胰胆表现和大出血。心血管和中枢神经系统表现发生在发热期或少尿期，而胰胆表现和大出血甚至在利尿期也能检测到。因此，需要密切监测和进一步了解各种肾外表现。
