Institut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasitology and Mycology, 28 rue du Docteur Roux, Paris 75015, France.
Science. 2011 Feb 4;331(6017):596-8. doi: 10.1126/science.1196759.
Population subgroups of the African malaria vector Anopheles gambiae have not been comprehensively characterized owing to the lack of unbiased sampling methods. In the arid savanna zone of West Africa, where potential oviposition sites are scarce, widespread collection from larval pools in the peridomestic human habitat yielded a comprehensive genetic survey of local A. gambiae population subgroups, independent of adult resting behavior and ecological preference. A previously unknown subgroup of exophilic A. gambiae is sympatric with the known endophilic A. gambiae in this region. The exophilic subgroup is abundant, lacks differentiation into M and S molecular forms, and is highly susceptible to infection with wild Plasmodium falciparum. These findings might have implications for the epidemiology of malaria transmission and control.
由于缺乏无偏采样方法，非洲疟疾传播媒介冈比亚按蚊的亚种群尚未得到全面描述。在西非干旱稀树草原地区，潜在的产卵地稀缺，因此从家庭周围的幼虫池中广泛采集样本，可以对当地冈比亚按蚊的亚种群进行全面的遗传调查，而无需考虑成蚊的休息行为和生态偏好。在该地区，一种以前未知的嗜人型冈比亚按蚊亚种群与已知的嗜内型冈比亚按蚊共存。这种嗜人型亚种群数量丰富，没有分化成 M 和 S 分子形式，对野生疟原虫感染高度敏感。这些发现可能对疟疾传播和控制的流行病学产生影响。
