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Circ Res. 2011 Feb 4;108(3):378-96. doi: 10.1161/CIRCRESAHA.110.224287.
Chromatin regulation provides an important means for controlling cardiac gene expression under different physiological and pathological conditions. Processes that direct the development of normal embryonic hearts and pathology of stressed adult hearts may share general mechanisms that govern cardiac gene expression by chromatin-regulating factors. These common mechanisms may provide a framework for us to investigate the interactions among diverse chromatin remodelers/modifiers and various transcription factors in the fine regulation of gene expression, essential for all aspects of cardiovascular biology. Aberrant cardiac gene expression, triggered by a variety of pathological insults, can cause heart diseases in both animals and humans. The severity of cardiomyopathy and heart failure correlates strongly with abnormal cardiac gene expression. Therefore, controlling cardiac gene expression presents a promising approach to the treatment of human cardiomyopathy. This review focuses on the roles of ATP-dependent chromatin-remodeling factors and chromatin-modifying enzymes in the control of gene expression during cardiovascular development and disease.
染色质调控为控制不同生理和病理条件下的心脏基因表达提供了重要手段。指导正常胚胎心脏发育和应激成年心脏病理过程的机制可能共享通过染色质调节因子控制心脏基因表达的一般机制。这些共同的机制可能为我们提供了一个框架，用于研究不同的染色质重塑因子/修饰因子和各种转录因子在基因表达精细调控中的相互作用，这对于心血管生物学的各个方面都是必不可少的。由各种病理损伤引发的异常心脏基因表达可导致动物和人类的心脏病。心肌病和心力衰竭的严重程度与异常心脏基因表达密切相关。因此，控制心脏基因表达为治疗人类心肌病提供了一种有前途的方法。本综述重点介绍了 ATP 依赖性染色质重塑因子和染色质修饰酶在心血管发育和疾病过程中控制基因表达的作用。
