Desai Neeraj R, Palomino Jaime, Hayek Hafez, Shames Jay, Simeone Francesco
Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University Health Sciences Center, New Orleans, USA.
J La State Med Soc. 2010 Nov-Dec;162(6):346-9.
Swyer-James Macleod syndrome is a rare disorder that leads to recurrent respiratory infections. The fibrosis and obstruction of the terminal and respiratory bronchioles, likely caused by respiratory infections in early childhood, prevents normal development of the alveolar bud. Organisms that have been associated with this syndrome include adenovirus, measles, bordetella pertussis, mycobacterium spp, influenza A and mycoplasma. The syndrome is an acquired cause of unilateral emphysema. The diagnosis of the syndrome can be made in infancy or early childhood, but in asymptomatic individuals can be delayed until adulthood and rarely in the elderly. Chest radiographs and computed tomographic (CT) scan can confirm the diagnosis and exclude other possibilities. A case of Swyer- James Macleod syndrome diagnosed at age 63 in a patient with recurrent respiratory infections and a history of childhood pertussis is presented.
斯怀尔-詹姆斯-麦克劳德综合征是一种罕见的疾病，可导致反复呼吸道感染。终末细支气管和呼吸性细支气管的纤维化及阻塞，可能由儿童早期的呼吸道感染引起，会妨碍肺泡芽的正常发育。与该综合征相关的病原体包括腺病毒、麻疹、百日咳博德特氏菌、分枝杆菌属、甲型流感病毒和支原体。该综合征是单侧肺气肿的后天性病因。该综合征的诊断可在婴儿期或儿童早期做出，但对于无症状个体，诊断可能会延迟至成年期，在老年人中则很少见。胸部X光片和计算机断层扫描（CT）可确诊并排除其他可能性。本文报告了一例63岁诊断为斯怀尔-詹姆斯-麦克劳德综合征的患者，该患者有反复呼吸道感染史及儿童期百日咳病史。
