Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Honolulu, HI 96813, USA.
Cancer Epidemiol Biomarkers Prev. 2011 Apr;20(4):708-10. doi: 10.1158/1055-9965.EPI-10-1309. Epub 2011 Feb 4.
Coenzyme Q10 (CoQ10) is considered to be a potential anticancer agent, but epidemiologic evidence regarding CoQ10 and prostate cancer risk is lacking. We examined the association of circulating CoQ10 levels with prostate cancer risk, using prediagnostic blood samples.
Each of the 307 cases was individually matched to approximately 2 controls, for a total of 596 controls, on age, ethnicity, geographic location, date/time of specimen collection, and hours of fasting. Logistic regression was used to compute ORs and 95% CIs.
There was no overall statistically significant association of plasma CoQ10 levels with prostate cancer risk (P(trend) = 0.50). However, after matched sets in which controls who had possible undiagnosed prostate cancer (prostate specific antigen value >4.0) were excluded, the ORs for quintiles 2 to 5 were all less than 1.0.
The results suggest the possibility that moderate levels of circulating CoQ10 may be optimal for the reduction of prostate cancer risk; however, the findings were weak and not statistically significant. Because this is the first epidemiologic study of the association between CoQ10 and prostate cancer, further research on this topic is needed.
If a nutritional factor such as CoQ10 were determined to reduce prostate cancer risk, it would have considerable public health significance because of the very high incidence of this cancer.
辅酶 Q10（CoQ10）被认为是一种有潜力的抗癌药物，但关于 CoQ10 与前列腺癌风险的流行病学证据尚缺乏。我们使用前瞻性血样，研究了循环 CoQ10 水平与前列腺癌风险之间的相关性。
对每个病例（共 307 例），均按照年龄、种族、地理位置、标本采集时间和空腹时间，与大约 2 名对照进行个体匹配，共得到 596 名对照。采用 logistic 回归计算比值比（OR）及其 95%可信区间（CI）。
血浆 CoQ10 水平与前列腺癌风险之间并无总体统计学显著关联（趋势检验 P 值=0.50）。但是，在排除了对照中可能患有未确诊的前列腺癌（前列腺特异抗原值＞4.0）的匹配组中，五分位 2 到 5 的 OR 值均小于 1.0。
结果提示，循环 CoQ10 的中等水平可能最有利于降低前列腺癌风险，但发现较为微弱，且无统计学意义。由于这是 CoQ10 与前列腺癌相关性的第一项流行病学研究，因此需要对这一课题进行进一步研究。
如果某种营养因素（如 CoQ10）被确定可降低前列腺癌风险，鉴于这种癌症的极高发病率，这将具有重要的公共卫生意义。
